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	Provedor de dados BJMBR (1) Autor Li,M. (1) Qi,X.L. (1) Tang,Z.Y. (1) Wang,L. (1) Wang,W. (1) Palavra-chave Amyotrophic lateral sclerosis (1) C282Y (1) H63D (1) HFE (1) Meta-analysis (1) Polymorphism (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies BJMBR Li,M.; Wang,L.; Wang,W.; Qi,X.L.; Tang,Z.Y.. Iron homeostasis dysregulation has been regarded as an important mechanism in neurodegenerative diseases. The H63D and C282Y polymorphisms in theHFE gene may be involved in the development of sporadic amyotrophic lateral sclerosis (ALS) through the disruption of iron homeostasis. However, studies investigating the relationship between ALS and these two polymorphisms have yielded contradictory outcomes. We performed a meta-analysis to assess the roles of the H63D and C282Y polymorphisms of HFEin ALS susceptibility. PubMed, MEDLINE, EMBASE, and Cochrane Library databases were systematically searched to identify relevant studies. Strict selection criteria and exclusion criteria were applied. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Amyotrophic lateral sclerosis; HFE; C282Y; H63D; Polymorphism; Meta-analysis. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300215 Registros recuperados: 1 Primeira ... 1 ... Última

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