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| ROTHHAMMER,FRANCISCO; SANTORO,CALOGERO M; POULIN,ELIE; ARRIAZA,BERNARDO T; MORAGA,MAURICIO; STANDEN,VIVIEN J. |
| The influence of tropical lowland migrations on the emergence of cultural change in the Central Andes has been postulated in general terms since the beginning of last century (Tello 1929). Archeological and molecular genetic evidence, particularly agriculture of tropical cultigens and ancient mtDNA haplogroup typing in northern Chile, suggest a chronologically more precise relationship between both regions. We test in this article the hypothesis that the process of cultural transformation of prehistoric populations living on the coast and the desert valleys of northern Chile can be partially linked to gene flow from the eastern slopes of the Andes and/or from the tropical lowlands during the Late Archaic / Formative periods (ca. 3,500-2,000 B.P.). |
| Tipo: Journal article |
Palavras-chave: Ancient mtDNA; Central Andes; Cultural change; Tropical lowland migration. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2009000400008 |
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| GARCÍA,FEDERICO; MORAGA,MAURICIO; VERA,SOLEDAD; HENRÍQUEZ,HUGO; LLOP,ELENA; OCAMPO,CARLOS; ASPILLAGA,EUGENIO; ROTHHAMMER,FRANCISCO. |
| Las etnias originarias del archipiélago de Chiloé presentan características culturales que plantean preguntas acerca de su origen como entidad genética independiente y distinta del grupo continental. Al respecto, hemos caracterizado las frecuencias de los cuatro haplogrupos amerindios fundadores del ADN mitocondrial en cuatro poblaciones del archipiélago. El componente aborigen materno de estas poblaciones fue superior al 90 %. El análisis de distancias genéticas sugiere una segregación norte-sur en donde las poblaciones septentrionales aparecen más relacionadas con la etnia continental Huilliche. Aún cuando el análisis de diferenciación interpoblacional y de componentes principales muestran una singularidad en el grupo insular, ésta puede ser interpretada... |
| Tipo: Journal article |
Palavras-chave: Chiloé; Diversidad étnica; Diversidad genética humana; ADN. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2004000300012 |
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| MORAGA,MAURICIO; ASPILLAGA,EUGENIO; SANTORO,CALOGERO; STANDEN,VIVIEN; CARVALLO,PILAR; ROTHHAMMER,FRANCISCO. |
| La hipótesis del origen amazónico de las poblaciones andinas basada en el análisis de marcadores genéticos nucleares es contrastada haciendo uso de ADN mitocondrial antiguo aislado de restos esqueletales de poblaciones prehistóricas del Valle de Azapa, Arica, Chile. Se analizaron 42 muestras de las cuales 32 rindieron amplificados para los cuatro marcadores amerindios permitiendo su tipificación. La distribución de haplogrupos (A: 31,2 %, B: 21,9 %, C: 31,2 %, D: 3,1 % y otros 12,5 %) relaciona genéticamente a las poblaciones estudiadas con grupos amazónicos y andinos actuales. El número de muestras analizadas no permite aún una subdivisión por fases cronológicas con el objeto de poner a prueba las hipótesis planteadas por arqueólogos y bioantropológos... |
| Tipo: Journal article |
Palavras-chave: Origen amazónico de poblaciones andinas; Restos esqueléticos; ADNmt antiguo; Microevolución biocultural; Valle de Azapa. |
| Ano: 2001 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2001000300018 |
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| OJEDA,JOSÉ M; AMPUERO,SANDRA; ROJAS,PATRICIO; PRADO,RODRIGO; ALLENDE,JORGE E; BARTON,SARA A; CHAKRABORTY,RANAJIT; ROTHHAMMER,FRANCISCO. |
| Storey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. These authors further noted that in the United Kingdom, individuals homozygous for the arginine allele were several times more susceptible to HPV-associated tumorigenesis that proline/arginine heterozygotes. Subsequent studies in different countries failed to unanimously confirm this association. Motivated by the high incidence of CC in Chile, we undertook a case control study obtaining the following frequencies for genotypes PP, AP... |
| Tipo: Journal article |
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| Ano: 2003 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200017 |
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| LÓPEZ,JAVIER; LÓPEZ,VLADIMIR; ROJAS,DANIEL; CARRASCO,XIMENA; ROTHHAMMER,PAULA; GARCÍA,RICARDO; ROTHHAMMER,FRANCISCO; ABOITIZ,FRANCISCO. |
| Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different neural systems. In this study we measured the effect of stimulants on ADHD children, both in the electroencephalographic (EEG) activity during sustained attentional tasks and in psychometric performance during selective attentional tasks. These tasks are known to rely on different cortical networks. Our results in children medicated with 10 mg of d-amphetamine administered 60 min before the study indicate (i) a significant increase in amplitude but not latency of the P300 component of the event-related potential... |
| Tipo: Journal article |
Palavras-chave: Attentional deficit; EEG; Event-related potentials; Hyperactivity; Stroop; P300. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300010 |
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