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	Provedor de dados BJPS (2) Autor Ricci Júnior,Eduardo (2) Dysars,Letícia Pereira (1) Girard-Dias,Wendell (1) Guerreiro,Luiz Henrique (1) Lima,Luís Mauricio Trambaioli da Rocha e (1) Mascarenhas,Camile Moreira (1) Miranda,Kildare (1) Santos,Elisabete Pereira dos (1) Silva,Daniel da (1) Silva,Márcio Robert Mattos da (1) Sola-Penna,Mauro (1) Mais... Palavra-chave Extemporaneous oral liquid (1) Hospital pharmacy (1) Human insulin/study (1) Microparticles (1) Poly-ε-caprolactone (1) Proteins/molecular entrapping (1) Stability (1) Therapeutic proteins/study/action (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Preparation of extemporaneous oral liquid in the hospital pharmacy BJPS Silva,Márcio Robert Mattos da; Dysars,Letícia Pereira; Santos,Elisabete Pereira dos; Ricci Júnior,Eduardo. At the hospital, the pharmacist is constantly challenged to prepare extemporaneous solutions from tablets, capsules or drug powder for patients unable to swallow, such as pediatric, elderly and patients that use nasoenteric and nasogastric tubes. The preparation of extemporaneous solutions from capsules, tablets and drug powder requires stability studies analysis. This article is a bibliographic review of preparation of extemporaneous oral liquid from solid oral dosage forms used in clinical practice. The selected articles contain all the information regarding manipulation techniques, pharmaceutical excipients, packaging, storage conditions and results of stability studies above 90% performed by HPLC analysis. In addition, a situational analysis of the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Extemporaneous oral liquid; Stability; Hospital pharmacy. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100703 Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study BJPS Guerreiro,Luiz Henrique; Silva,Daniel da; Girard-Dias,Wendell; Mascarenhas,Camile Moreira; Miranda,Kildare; Sola-Penna,Mauro; Ricci Júnior,Eduardo; Lima,Luís Mauricio Trambaioli da Rocha e. ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability. We have developed a micro-structured poly-epsilon-caprolactone (PCL) particle system loaded with human insulin using a simple double-emulsion w/o/w method followed by solvent evaporation method. This formulation is comprised by spheric-shaped microparticles with average size of 10 micrometers. In vitro release showed a biphasic behavior such as a rapid release with about 50% of drug delivered within 2 hours and a sustained phase for up to 48 h. The subcutaneous administration of microencapsulated insulin showed a biphasic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human insulin/study; Microparticles; Poly-ε-caprolactone; Therapeutic proteins/study/action; Proteins/molecular entrapping. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200622 Registros recuperados: 2 Primeira ... 1 ... Última

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