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Radiopharmaceuticals drug interactions: a critical review Anais da ABC (AABC)
Santos-Oliveira,Ralph; Smith,Sheila W.; Carneiro-Leão,Ana Maria A..
Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment. As the use of image has been increased, so has the use of prescription medications. These trends increase the risk of interactions between medications and radiopharmaceuticals. These interactions which have an impact on image by competing with the radiopharmaceutical for binding sites for example can lead to false negative results. Drugs that accelerate the metabolism of the radiopharmaceutical can have a positive impact (i.e. speeding its clearance) or, if repeating image is needed, a negative impact. In some cases, for example in cardiac image among patients taking doxirubacin, these...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Radiopharmacy; Drug interaction; Systematic review.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000400008
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Influence of radiation on endotoxin test using the PTS TM for 18-FDG radiopharmaceutical BJPS
Santos-Oliveira,Ralph.
F-18 FDG (2-[18-F] fluoro-2-deoxy-D-glucose) is the most frequently used radiopharmaceutical for PET and PET CT imaging exams. The FDA recently approved the use of the PTS TM (Portable Test System) as an alternative to the standard test proposed by the United States Pharmacopeia using the LAL (Limulus Amebocyte Lysates), that takes longer to perform (about 1h) than the PTS TM (15 min). Recent studies have demonstrated that radiation could interfere with the PTS TM test. In order to study the effects of radiation on the PTS TM test and/or equipment, 27 batches of F-18 FDG produced in the Nuclear Engineering Institute were analyzed. The results showed that no direct correlation with radiation was found in any of the cases.
Tipo: Info:eu-repo/semantics/article Palavras-chave: 18-FDG/utilization; Radiopharmaceuticals; Nuclear medicine; Endotoxin test; Portable Test System/radiation effects.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300019
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Obligations, precautions and pending issues in regulatory development for radiopharmaceuticals in Brazil BJPS
Gamboa,Maryelle Moreira Lima; Roesch,Heveline Rayane Moura; Lemos,Vanessa Pinheiro Amaral; Rocha,Bruna Oliveira; Santos-Oliveira,Ralph.
Radiopharmaceuticals are compounds that have a radionuclide and may be gamma-radiation emitter (γ) or positrons emitter (β+), linked to a molecule with specific diagnostic and therapeutic purposes. The progress in the use of radiopharmaceuticals has culminated to a sector in common with other types of drugs: regulation and surveillance. From 2006 on, production, marketing and use of these drugs were open to the Brazilian market granting much more freedom due to the Constitutional Amendment 49, resulting from the previous Constitutional Amendment 199/03 which removes the Union monopoly for this kind of manipulation and granted this production to other nuclear medicine. From this date on, the amount of this type of sold product have been greatly increased,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals/regulation; Radiopharmaceuticals/ surveillance; Radiopharmaceuticals/pharmacovigilance; Pharmacovigilance/practice in radiopharmaceuticals drugs; Brazilian legislation/radiopharmaceuticals control.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200285
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Guidance for nuclear medicine staff on radiopharmaceuticals drug interaction BJPS
Santos-Oliveira,Ralph.
Numerous drug interactions related to radiopharmaceuticals take place every day in hospitals many of which are not reported or detected. Information concerning this kind of reaction is not abundant, and nuclear medicine staff are usually overwhelmed by this information. To better understand this type of reaction, and to help nuclear medicine staff deal with it, a review of the literature was conducted. The results show that almost all of radiopharmaceuticals marketed around the world present drug interactions with a large variety of compounds. This suggests that a logical framework to make decisions based on reviews incorporating adverse reactions must be created. The review also showed that researchers undertaking a review of literature, or even a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nuclear medicine; Radiology; Radiopharmaceuticals/drug interaction; Molecular imaging.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400003
Registros recuperados: 4
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