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Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Azoubel,Reinaldo; Sala,Miguel A; Mattos,Maria G. C; Hallak Regalo,Simone Cecílio. |
Phenytoin (diphenylhydantoin, dilantin) has been the chosen anti-convulsive for the treatment of sudden disorders since the late 1930's. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestation, such as cranio-facial development and growth abnormalities, distal phalangeal hypoplasia, and light or moderate mental deficiency. This work had the goal to study the lingual mucosa, under histopathological and morphometric standpoints, in rat fetuses which were given an intraperitonial injection, consisting of a unique dose of phenytoin (70 milligrams/kilogram of their weight). Being that, we included the examined material in paraffin, 6 micrometers thick, and... |
Tipo: Journal article |
Palavras-chave: Phenytoin; Lingual mucosa; Rat; Morphometry. |
Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200009 |
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Watanabe,Plauto Christopher Aranha; Issa,João Paulo Mardegan; Oliveira,Tatiane Martín de; Monteiro,Solange Aparecida Caldeira; Iyomasa,Mamie Mizusaki; Regalo,Simone Cecilio Hallak; Siéssere,Selma. |
The aim of this study was to correlate the morphodigital characteristics of the trabecular mandibular bone, in this way, it is possible to observe osteoporosis clue in patients of both sex, using panoramic radiograph for analysis. The results of this study showed statistical difference between men and women considering the bone trabecular measures (p<0.05), but it was not found statistical difference between the sides in each analyzed group (p>0.05). Male group presented a more strongly trabecular and complex bone than the female group, this finding is important index to osteoporotic risk, being possible to affirm that the male bone is less probable to suffer a osteoporotic fracture |
Tipo: Journal article |
Palavras-chave: Mandible; Bone; Digital image; Radiograph. |
Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400031 |
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Falcão-Filho,Hilmo Barreto Leite; Issa,João Paulo Mardegan; Nascimento,Cássio do; Iyomasa,Mamie Mizusaki; Regalo,Simone Cecilio Hallak; Siéssere,Selma; Pedrazzi,Vinicius; Pitol,Dimitrius Leonardo. |
The aim of this study was to present a possible carrier for MTA, monoolein gel, with the objective to maintain this material in the place that was inserted and verify if this procedure is able to optimize its action. The data were evaluated by histomorphometric method and submitted to statistical analysis. The histological responses observed in this study indicate that the MTA is a reliable material and should be considered effective in bone periapical defects and the monoolein gel was capable to maintain the MTA in situ |
Tipo: Journal article |
Palavras-chave: MTA; Monoolein gel; Histomorphometry; Periapical defect. |
Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400017 |
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Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Sala,Miguel A; Mattos,Maria G. C. |
Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal... |
Tipo: Journal article |
Palavras-chave: Valproic acid; Rat; Meckel's cartilage; Lingual musculature; Submandibular gland. |
Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006 |
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Issa,Joao Paulo Mardegan; Petenusci,Sergio Olavo; Siéssere,Selma; Regalo,Simone Cecilio Hallak; Lopes,Ruberval Armando; Di Matteo,Miguel Ángel Sala; Iyomasa,Mamie Mizusaki; Defino,Helton Luiz Aparecido. |
The aim of this study was to evaluate the calcium dosage of the newly formed bone, in critical bone defects created on the calvarial tissue and filled by different substances, in male Wistar rats. A cylindrical critical bone defect (6x2mm) was created in the posterior portion, left side, on the calvarial bone in nine animals and filled with: animals' coagulum, monoolein gel, poloxamer gel, monoolein gel + 1µg rhBMP-2, monoolein gel + 3µg rhBMP-2, monoolein gel + 7µg rhBMP-2, poloxamer gel + 1µg rhBMP-2, poloxamer gel + 3µg rhBMP-2, poloxamer gel + 7µg rhBMP-2. The results of this study showed a positive correlation between the calcium dosage analysis and the newly formed bone |
Tipo: Journal article |
Palavras-chave: Bone repair; Biomaterials; RhBMP-2; Carriers; Calcium. |
Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300006 |
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Issa,João Paulo Mardegan; Tiossi,Rodrigo; Watanabe,Plauto Christopher Aranha; Siéssere,Selma; Regalo,Simone Cecílio Hallak; Lopes,Ruberval Armando; Di Matteo,Miguel Angel Sala; Iyomasa,Mamie Mizusaki; Defino,Helton Luiz Aparecido. |
The purpose of this study was to evaluate the newly formed bone, comparing two different carriers for rhBMP-2, using the decortication and nondecorticatication surgical technique in Wistar rat mandibles, evaluated by radiographic densitometry method. It was used fifty six animals according to specific treatment, which were sacrificed after 3 and 6 weeks after this. It was concluded that the decortication surgical technique was able to optimize the osteoinduction properties of the rhBMP-2, independently of the material carrier used and the period of time, according to radiographic densitometry technique. |
Tipo: Journal article |
Palavras-chave: Radiography; Densitometry; Mandible; RhBMP-2; Bone. |
Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100014 |
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