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| Nicolau,L.A.D.; Silva,R.O.; Damasceno,S.R.B.; Carvalho,N.S.; Costa,N.R.D.; Aragão,K.S.; Barbosa,A.L.R.; Soares,P.M.G.; Souza,M.H.L.P.; Medeiros,J.V.R.. |
| Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson's reagent (3, 9, or 27 µmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the animals were killed 4 h after ALD administration. Gastric lesions were measured using a computer planimetry program, and gastric corpus pieces were assayed for malondialdehyde (MDA), glutathione (GSH), proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-1β], and myeloperoxidase (MPO). Other groups were pretreated with glibenclamide (5 mg/kg, ip) or with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alendronate; Lawesson's reagent; H2S donors; Gastric damage. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800708 |
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| Souza Filho,M.V.P.; Loiola,R.T.; Rocha,E.L.; Simão,A.F.L.; Gomes,A.S.; Souza,M.H.L.P.; Ribeiro,R.A.. |
| Ischemic preconditioning (IPC), a strategy used to attenuate ischemia-reperfusion injury, consists of brief ischemic periods, each followed by reperfusion, prior to a sustained ischemic insult. The purpose of the present study was to evaluate the local and systemic anti-inflammatory effects of hind limb IPC in male Wistar rat (200-250 g) models of acute inflammation. IPC was induced with right hind limb ischemia for 10 min by placing an elastic rubber band tourniquet on the proximal part of the limb followed by 30 min of reperfusion. Groups (N = 6-8) were submitted to right or left paw edema (PE) with carrageenan (100 µg) or Dextran (200 µg), hemorrhagic cystitis with ifosfamide (200 mg/kg, ip) or gastric injury (GI) with indomethacin (20 mg/kg, vo).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ischemic preconditioning; Carrageenan; Dextran; Ifosfamide; Indomethacin. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001000008 |
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| Souza,M.H.L.P.; Troncon,L.E.A.; Cunha,F.Q.; Oliveira,R.B.. |
| Gastric antral dysmotility has been implicated in the pathogenesis of indomethacin-induced gastric damage, but the relationship between gastric motor abnormalities and mucosal lesions has not been extensively studied. We investigated whether changes in gastric tone and gastric retention correlate with mucosal lesions and neutrophil migration in indomethacin-induced gastric damage in rats. Indomethacin, either 5 or 20 mg/kg (INDO-5 and INDO-20), was instilled into the stomach, and then gastric damage, neutrophil migration, gastric tone and gastric retention were assessed 1 or 3 h later. Gastric damage was calculated as the sum of the lengths of all mucosal lesions, and neutrophil migration was measured by assaying myeloperoxidase activity. Gastric tone was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gastric emptying; Gastric tone; Indomethacin; Gastric damage; Neutrophil. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000015 |
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