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| Gong,Jian; Li,Dongzhi; Yan,Jun; Liu,Yu; Li,Di; Dong,Jie; Gao,Yaping; Sun,Tao; Yang,Guang. |
| Background:Intracranial abscesses are associated with high mortality. Staphylococcus aureus is one of the main pathogens that cause intracranial infection. Until now, there is no report to identify the key effectors of S. aureus during the intracranial infection.Methods:The murine intracranial abscesses model induced by S. aureuswas constructed. The vital sign and survival rate of mice were observed to evaluate the infection. Histological examination was used to diagnose the pathological alterations of mouse tissues. The sensitivity of S. aureus to whole blood was evaluated by whole-blood killing assay.Results:In murine intracranial abscesses model, it was shown that the mortality caused by the accessory gene regulator (agr) locus deficient strain was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: S. aureus; Agr; Intracranial abscesses model. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500501 |
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