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Reduction of b-Glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model Biocell
de Moreno de LeBlanc,A.; Perdigón,G..
Yoghurt feeding inhibits induced colon cancer in mice. Several studies showed the immunomodulatory effect of yoghurt which can explain this inhibition. It is possible that yoghurt bacteria can also affect gut flora enzymes related to colon carcinogenesis as reported for other probiotics in different animal tumours. The aim of this work was to evaluate the role of yoghurt starter bacteria and their cell-free fermentation products on the reduction of procarcinogen enzyme activities (beta-glucuronidase and nitroreductase). Mice injected with 1,2-dimethylhydrazine (DMH) and fed with yoghurt were used for this study. Mice given milk or yoghurt supernatant (cell free extract) were used to evaluate if the yoghurt antitumour effect is due to the starter bacteria...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Colon cancer; Yoghurt; Starter bacteria; Beta-glucuronidase; Nitroreductase.
Ano: 2005 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452005000100003
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