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Adrenoceptors of the medial septal area modulate water intake and renal excretory function induced by central administration of angiotensin II BJMBR
Saad,W.A.; Guarda,I.F.M.S.; Camargo,L.A.A.; Santos,T.A.F.B.; Simões,S.; Saad,Willian A..
We investigated the role of a-adrenergic antagonists and clonidine injected into the medial septal area (MSA) on water intake and the decrease in Na+, K+ and urine elicited by ANGII injection into the third ventricle (3rdV). Male Holtzman rats with stainless steel cannulas implanted into the 3rdV and MSA were used. ANGII (12 nmol/µl) increased water intake (12.5 ± 1.7 ml/120 min). Clonidine (20 nmol/µl) injected into the MSA reduced the ANGII-induced water intake (2.9 ± 0.5 ml/120 min). Pretreatment with 80 nmol/µl yohimbine or prazosin into the MSA also reduced the ANGII-induced water intake (3.0 ± 0.4 and 3.1 ± 0.2 ml/120 min, respectively). Yohimbine + prazosin + clonidine injected into the MSA abolished the ANGII-induced water intake (0.2 ± 0.1 and 0.2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: A-Adrenoceptors; Angiotensin II; Water intake; Sodium; Potassium; Water excretion; Medial septal area.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800012
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