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PP65 antigenemia in the diagnosis of cytomegalovirus infection in AIDS patients J. Venom. Anim. Toxins incl. Trop. Dis.
Capela,RC; Grassi,A; Souza,LR.
Cytomegalovirus causes significant morbidity and mortality in AIDS patients and those having undergone bone marrow or another transplant. PP65 antigenemia is based on detecting viral antigen in peripheral blood leukocytes through immunochemistry and by monitoring the infection in immunocompromised individuals. The present study aimed to set up this diagnostic technique in AIDS patients with active cytomegalovirus infection and verify its occurrence in the Botucatu region of São Paulo state, Brazil. Fifty patients, 35 men and 15 women aged from 24 to 69 years, were recruited from those attended at the Department of Tropical Diseases of Botucatu Medical School, UNESP, and divided into three groups according to CD4+ T lymphocyte counts and antiretroviral...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acquired immunodeficiency syndrome; Cytomegalovirus; Pp65 antigen; Laboratory diagnosis.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100013
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Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil J. Venom. Anim. Toxins incl. Trop. Dis.
De Oliveira,SMVL; Paniago,AMM; Bonecini-Almeida,MG; Bertoni,N; Stabile,AC; Da Cunha,RV; De Oliveira,OA; Druzian,AF; Negri,AC; Andreotti,R.
A cross-sectional study on HIV/AIDS was carried out in 108 outpatients from the university hospital of the Federal University of Mato Grosso do Sul, Campo Grande, Brazil, from July to December 2008, to investigate latent tuberculosis infection using the tuberculin skin test (TST). The prevalence of positive results was 13.9%. The CD4+ T cell count (p = 0.091) and the diagnosis time (p = 0.010) were statistically significant when compared with TST positivity. In the cohort of HIV/AIDS patients who had latent tuberculosis infection, the median diagnosis time was eight years. Undetectable viral load presented significant association (p = 0.046) with tuberculosis infection. The fact that numerous individuals with HIV/AIDS infection presented a negative...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculin skin test; Acquired immunodeficiency syndrome; CD4/CD8 cell count.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200010
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Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis andMycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review BJID
Coelho,Lara; Veloso,Valdiléa Gonçalves; Grinsztejn,Beatriz; Luz,Paula Mendes.
BACKGROUND:The natural history of HIV infection has changed dramatically after the introduction of highly active antiretroviral therapy. Currently, opportunistic illnesses still represent a major cause of death and hospitalization in this population. In this study, we review the trends in opportunistic illnesses incidence rates and compare the results observed in high-income settings with that for low/middle-income settings, with special attention given to studies from Brazil.METHODS:We systematically searched Pubmed, Web of Science, Lilacs and Google scholar for publications on HIV associated opportunistic illness. Studies reporting rates based on person-time for all opportunistic illnesses and/or the three opportunistic infections of interest,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: AIDS-related opportunistic infections; Opportunistic infection; Acquired immunodeficiency syndrome; Incidence.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200196
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Improving survival among Brazilian children with perinatally-acquired AIDS BJID
Matida,Luiza Harunari; Marcopito,Luiz Francisco; Succi,Regina Celia de Menezes; Marques,Heloisa Helena de Souza; Della Negra,Marinella; Grangeiro,Alexandre; Hearst,Norman.
Brazil was the first developing country to provide free, universal access to antiretroviral treatment for AIDS patients. The Brazilian experience thus provides the first evidence regarding the impact of such treatment on the survival of perinatally acquired AIDS cases in the developing world. MATERIAL AND METHODS: This retrospective cohort study used medical record reviews to examine characteristics and trends in the survival of a representative sample of 914 perinatally acquired AIDS cases in 10 Brazilian cities diagnosed between 1983 and 1998. RESULTS: Survival time increased steadily and substantially. Whereas half of the children died within 20 months of diagnosis at the beginning of the epidemic, 75% of children diagnosed in 1997 and 1998 were still...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acquired immunodeficiency syndrome; Brazil; Human immunodeficiency virus; Pediatric; Perinatal transmission; Survival.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600005
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Reiter's Syndrome associated with the Acquired Immunodeficiency Syndrome: a case report BJID
Malta,J.B.N.S.; Milanelo,D.; Carvalheiro,F.A.R.; Silva,M.V..
The association of Reiter's Syndrome (RS) with the Acquired Immunodeficiency Syndrome (AIDS) is seldom mentioned in the medical literature. This report illustrates this relationship in a 46 years old male patient suffering from AIDS (CD4+ = 240 cells/mm³, CD8+ = 1,301 cells/mm³ and viral load = 330,000 copies/ml), pulmonary tuberculosis (positive catarrhal bacilluscopy), and RS. The diagnosis of RS was based on the combination of dermatological and articular alterations. The patient's cutaneous lesions were characterized by exfoliation and the formation of crusts located on the face, scalp, genitals, hands, and feet; onychodystrophy with opacity; yellowish coloring; and hyperkeratosis of the nails. Articular lesions led to progressive deformity of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Reiter's syndrome; Acquired immunodeficiency syndrome; AIDS.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100006
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Vaccination status of people living with HIV/AIDS in outpatient care in Fortaleza, Ceará, Brazil BJID
Cunha,Gilmara Holanda da; Galvão,Marli Teresinha Gimeniz; Medeiros,Camila Martins de; Rocha,Ryvanne Paulino; Lima,Maria Amanda Correia; Fechine,Francisco Vagnaldo.
Abstract Antiretroviral therapy has increased the survival of patients with HIV/AIDS, thus necessitating health promotion practice with immunization. Vaccines are critical components for protecting people living with HIV/AIDS (PLWHA). The purpose of study was to analyze the vaccination status of PLWHA in outpatient care in Fortaleza, Ceará, Brazil. Cross-sectional study performed from June 2014 to June 2015. The screening was done with patients in antiretroviral therapy, 420 patients underwent screening, but only 99 met the inclusion criteria. Data were collected for interviews using forms to characterize sociodemographic, clinical and vaccination situations. Only 14 patients had complete vaccination schedules. The most used vaccines were hepatitis B,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acquired immunodeficiency syndrome; HIV; Health promotion; Immunization; Immunization schedule.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500487
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Factors associated with epidemic multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions BJID
Gomes,Marisa Zenaide Ribeiro; Oliveira,Raquel Vasconcellos C. de; Machado,Carolina Romero; Conceição,Magda de Souza da; Souza,Cristina Vieira de; Lourenço,Maria Cristina da Silva; Asensi,Marise Dutra.
INTRODUCTION: Infections caused by multiresistant Pseudomonas aeruginosa (MR-PA) have been associated with persistent infections and high mortality in acquired immunodeficiency syndrome (AIDS) patients. Therefore, understanding the predisposing factors for infection/colonization by this agent is critical for controlling outbreaks caused by MR-PA in settings with AIDS patients. OBJECTIVEAND METHODS: To analyze the presence of factors associated with the acquisition of an epidemic MR-PA strain in a hospital with AIDS-predominant admission. A case-control study was carried out in which cases and controls were gathered from a prospective cohort of all hospitalized patients in an infectious disease hospital during a five-year study period. RESULTS: Multivariate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pseudomonas aeruginosa; Risk factors; Disease outbreaks; Molecular epidemiology; Acquired immunodeficiency syndrome.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300001
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Survival analysis of acquired immune deficiency syndrome patients with and without hepatitis C virus infection at a reference center for sexually transmitted diseases/acquired immune deficiency syndrome in São Paulo, Brazil BJID
Alencar,Wong Kuen; Duarte,Paulo Schiavom; Waldman,Eliseu Alves.
INTRODUCTION:Survival of patients with acquired immune deficiency syndrome has improved with combination antiretroviral therapy; mortality due to liver diseases, however, has also increased in these patients.OBJECTIVES:To estimate the accumulated probability of survival in human immunodeficiency virus-hepatitis C virus coinfected and non-coinfected patients and to investigate factors related to acquired immune deficiency syndrome patients' survival.METHODS:Non-concurrent cohort study using data from surveillance information systems of acquired immune deficiency syndrome patients over 13 years of age. Hepatitis C and B, human immunodeficiency virus exposure category, CD4+ T cell count, age group, schooling, race, sex, and four acquired immune deficiency...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Acquired immunodeficiency syndrome; Hepatitis viruses; Survival analysis.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200150
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Osteoarticular complications related to HIV infection and highly active antiretroviral therapy BJID
Lima,Ana Lúcia Lei Munhoz; Zumiotti,Arnaldo Valdir; Camanho,Gilberto Luis; Benegas,Eduardo; Santos,Alexandre Leme Godoy dos; D'Elia,Caio Oliveira; Oliveira,Priscila Rosalba Domingos.
With the significant increase in life expectancy for HIV-infected patients in the era of high potency antiretroviral therapy, major metabolic changes have been observed due to the prolonged period of the viral infection and the treatment itself. Osteoarticular changes resulting from these processes are mainly reported in long term HIV-infected patients receiving high potency antiretroviral therapy and include osteopenia/osteoporosis, osteonecrosis, carpal tunnel syndrome and adhesive capsulitis of the shoulder.
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Acquired immunodeficiency syndrome; Osteoarticular; Antiretroviral agents.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400012
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Performance of an immunoenzymatic assay for Cryptosporidium diagnosis of fecal samples BJID
Marques,Fabiana Rangel; Cardoso,Luciana Ventura; Cavasini,Carlos Eugênio; Almeida,Magali Carmem de; Bassi,Nair Aparecida; Almeida,Margarete Teresa Gottardo de; Rossit,Andréa Regina Baptista; Machado,Ricardo Luiz Dantas.
We evaluated the diagnostic performance of a Cryptosporidium immunoenzymatic assay (ELISA). Fecal samples were collected from 94 HIV-seropositive patients. All specimens were processed with a commercially-available ELISA to detect C. parvum specific coproantigen and with a modified Ziehl-Neelsen stain (ZNm) microscope exam. Overall, sensitivity of the immunoenzymatic test was 100%, with a specificity of 96%; positive and negative predictive values were 89% and 100%, respectively. The commercial ELISA and ZNm proved to be valuable diagnostic tools for Cryptosporidium infection.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Parasites; Acquired immunodeficiency syndrome; Cryptosporidium diagnosis; Brazil.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100002
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Prevalence and factors associated with darunavir resistance mutations in multi-experienced HIV-1-infected patients failing other protease inhibitors in a referral teaching center in Brazil BJID
Vidal,Jose E; Freitas,Angela C; Song,Alice TW; Campos,Silvia V; Dalben,Mirian; Hernandez,Adrian V.
Information about resistance profile of darunavir (DRV) is scarce in Brazil. Our objectives were to estimate the prevalence of DRV resistance mutations in patients failing protease inhibitors (PI) and to identify factors associated with having more DRV resistance mutations. All HIV-infected patients failing PI-based regimens with genotyping performed between 2007 and 2008 in a referral teaching center in São Paulo, Brazil, were included. DRV-specific resistance mutations listed by December 2008 IAS-USA panel update were considered. Two Poisson regression models were constructed to assess factors related to the presence of more DRV resistance mutations. A total of 171 HIV-infected patients with available genotyping were included. The number of patients with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antiretroviral therapy; Highly active; HIV protease inhibitors; Acquired immunodeficiency syndrome; Brazil.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300011
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Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome BJID
Santos,Eder de Oliveira; Canela,João dos Reis; Monção,Henry Carlos Gomes; Roque,Mauro José Guedes.
Reactivation of chronic Chagas' disease is a rare condition and occurs only in immunosuppressed patients. We report a case of a patient with a rapid and fatal reactivation of Chagas' disease, manifested by meningoencephalitis, which lead to a diagnosis of acquired immunodeficiency syndrome (AIDS). We believe there is sufficient evidence to include the reactivation of Chagas' disease among the diagnostic criteria of AIDS in Human Immunodeficiency Virus (HIV) infection.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Chagas' disease; Trypanosoma cruzi; Acquired immunodeficiency syndrome; Human immunodeficiency virus; Meningoencephalitis.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600009
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Importance of high IgG anti-Toxoplasma gondii titers and PCR detection of T. gondii DNA in peripheral blood samples for the diagnosis of AIDS-related cerebral toxoplasmosis: a case-control study BJID
Vidal,José E; Diaz,Adrián Vladimir Hernández; Oliveira,Augusto César Penalva de; Dauar,Rafi Felicio; Colombo,Fabio Antonio; Chioccola,Vera Lucia Pereira.
BACKGROUND: Cerebral toxoplasmosis (CT) continues to cause significant morbidity and mortality in human immunodeficiency virus (HIV)-infected patients in Brazil. In clinical practice, the initial diagnosis is usually presumptive and alternative diagnosis tools are necessary. Our objective was to evaluate whether the detection of high titers of IgG anti-Toxoplasma gondii and T. gondii DNA in blood samples are associated with the diagnosis of CT. METHODS: In this case-control study we included 192 patients with HIV-1 infection: 64 patients with presumptive CT (cases) and 128 patients with other diseases (controls). Blood samples to perform indirect immunofluorescense reaction (IFI) to detect anti-T. gondii IgG antibodies and polymerase chain reaction (PCR)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Toxoplasmosis; Cerebral toxoplasmosis; Polymerase chain reaction; Diagnosis; Acquired immunodeficiency syndrome; Brazil.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400009
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Acute cor pulmonale due to lymphocytic interstitial pneumonia in a child with AIDS BJID
Moreira-Silva,Sandra Fagundes; Moreno,Linda Marly C.; Dazzi,Mariana; Freire,Consuelo Maria Caiafa; Miranda,Angelica Espinosa.
BACKGROUND: Acute cor pulmonale is a clinical syndrome with signs of right-sided heart failure resulting from sudden increase of pulmonary vascular resistance. CASE PRESENTATION: A five-year-old male, infected by human immunodeficiency virus (HIV), was admitted at the division of infectious diseases of this hospital with cough, tachydyspnea, fever, and breathing difficulty. Computed tomography scan showed ground-glass opacities, cystic lesions, and bronchiectasis. The patient had nasal flaring, intercostal and subcostal retractions, and keeled chest. Abdomen was depressible; liver was 3 cm from the right-costal border, while spleen was 6 cm from the left-costal border. Echocardiogram examinations showed signs of acute cor pulmonale characterized by...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Acquired immunodeficiency syndrome; Adult; Children; Respiratory tract infections.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300013
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Outbreaks, persistence, and high mortality rates of multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions BJID
Gomes,Marisa Zenaide Ribeiro; Machado,Carolina Romero; Conceição,Magda de Souza da; Ortega,Jois Alves; Neves,Sonia Maria Ferraz M; Lourenço,Maria Cristina da Silva; Asensi,Marise Dutra.
INTRODUCTION: Authors have reported increased incidence of multiresistant Pseudomonas aeruginosa (MR-PA) infections worldwide over the last decade. Researchers have proposed multifaceted approaches to control MR-PA infections, but none have been reported in the acquired immunodeficiency syndrome (AIDS) setting. OBJECTIVE AND METHODS: Herein we report the impact of a multifaceted intervention for controlling MR-PA over five years in a hospital with AIDS-predominant admissions and describe the clinical characteristics of MR-PA infection in our patient population. The clinical outcomes of infected patients and molecular characteristics of the isolated strains were used as tools for controlling MR-PA infection rates. RESULTS: Significant temporary decrease of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pseudomonas aeruginosa; Disease outbreaks; Infection control; Molecular epidemiology; Acquired immunodeficiency syndrome.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400003
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Meningoencephalitis and new onset of seizures in a patient with normal brain CT and multiple lesions on MRI BJID
Vidal,José E.; Spichler,Anne; Oliveira,Augusto C. P. de; Lomar,André Villela.
Toxoplasmic encephalitis is the most common cerebral mass lesion in patients with AIDS. The definitive diagnosis requires direct demonstration of the tachyzoite form of Toxoplasma gondii in cerebral tissue. The presumptive diagnosis is based on serology, clinical and radiological features, and on response to anti-Toxoplasma therapy. Typically, patients have a subacute presentation of focal neurological signs, with multiple lesions in computed tomography (CT) or magnetic resonance imaging (MRI). However, the neurological and CT scan spectrum is broad. We report a case of toxoplasmic encephalitis in a heterosexual man without prior history of HIV infection. He was admitted with four days of headache, confusion, and new onset of seizures. His brain CT...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Toxoplasmic encephalitis; Computadorized tomography; Magnetic resonance imaging; Acquired immunodeficiency syndrome.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100010
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High rate of virologic suppression with darunavir/ritonavir plus optimized background therapy among highly antiretroviral-experienced HIV-infected patients: results of a prospective cohort study in São Paulo, Brazil BJID
Vidal,José Ernesto; Song,Alice Tung Wan; Matos,Maria Laura; Bartmann,Daniel; Anjos,Guilherme dos; Miranda,Érique José Peixoto de; Freitas,Ângela Carvalho; Dalben,Mirian de Freitas; Santana,Claudinei; Segurado,Aluísio Cotrim; Barreto,Cláudia Cortese; Hernández,Adrián Vladimir.
OBJECTIVES: To assess the virologic and immunological response of darunavir/ritonavir plus optimized background therapy in highly antiretroviral-experienced HIV-infected patients in Brazil. METHODS: Prospective cohort study carried out in a tertiary center in Sao Paulo, Brazil. Three-class antiretroviral-experienced patients with confirmed virologic failure began darunavir/ritonavir plus optimized background therapy (nucleoside/tide reverse transcriptase inhibitors ± raltegravir ± enfuvirtide ± maraviroc) after performing a genotypic resistance assay. Clinical evaluation and laboratory tests were collected at baseline and at weeks 12, 24, and 48. Multivariate analysis was performed to identify predictors of virologic response at 48 weeks. RESULTS:...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Highly active antiretroviral therapy; Darunavir; Acquired immunodeficiency syndrome; Developing countries.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100007
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Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy BJMBR
Machado,F.R.; Pagliari,C.; Caiafa,H.; Tapajós,R.; Duarte,M.I.S..
The objective of the present study was to evaluate the duodenal mucosa of HIV-infected patients during antiretroviral therapy. This was an observational study conducted on HIV-positive patients and a control group. Group 1 comprised 22 HIV-negative individuals while 38 HIV-positive individuals were classified according to the CDC 1993 classification into group 2 (A1 or A2) or group 3 (B2, A3, B3, C2, C3). All subjects were submitted to upper gastrointestinal endoscopy with duodenal biopsies. Qualitative, semi-quantitative and quantitative histological analyses were performed. Results were considered significant when P < 0.05. A higher prevalence of inflammatory infiltrate and eosinophilia was observed in the HIV group, together with a reduction in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Intestinal histopathology; Cytokines; Human immunodeficiency virus; Acquired immunodeficiency syndrome; Antiretroviral therapy; CD4+.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100013
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Hypomagnesemia is a risk factor for nonrecovery of renal function and mortality in AIDS patients with acute kidney injury BJMBR
Biagioni Santos,M.S.; Seguro,A.C.; Andrade,L..
The objective of the present study was to determine the prevalence of electrolyte disturbances in AIDS patients developing acute kidney injury in the hospital setting, as well as to determine whether such disturbances constitute a risk factor for nephrotoxic and ischemic injury. A prospective, observational cohort study was carried out. Hospitalized AIDS patients were evaluated for age; gender; coinfection with hepatitis; diabetes mellitus; hypertension; time since HIV seroconversion; CD4 count; HIV viral load; proteinuria; serum levels of creatinine, urea, sodium, potassium and magnesium; antiretroviral use; nephrotoxic drug use; sepsis; intensive care unit (ICU) admission, and the need for dialysis. Each of these characteristics was correlated with the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acquired immunodeficiency syndrome; Acute kidney failure; Water-electrolyte imbalance; Magnesium deficiency; Drug toxicity.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300015
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