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Chronic Stress Effects on Adrenal Cortex Cellular Proliferation in Pregnant Rats International Journal of Morphology
Bozzo,Aída Andrea; Soñez,Carlos Alberto; Monedero Cobeta,Ignacio; Avila,Rodolfo; Rolando,Alicia Nélida; Romanini,María Cristina; Lazarte,Mario; Gauna,Héctor Fernando; Mugnaini,María Teresa.
Chronic stress by immobilization during pregnancy may cause alterations in mechanisms maintaining homeostasis in the adrenal gland. The objective of this study was to quantify cellular proliferation index in the adrenal cortex during pregnancy second half and assess the effects of chronic stress on it. Adrenal cortex proliferation index in stressed rats showed a significant decrease at 12 and 17 days of gestation, while at day 21 it did not show differences with the control treatments. Moreover, proliferation index of reticular zones in control and experimental rats, exhibited a significant reduction in comparison to glomerular and fascicular zones of adrenal cortex during the three gestation days studied. In conclusion, chronic stress by immobilization...
Tipo: Journal article Palavras-chave: Chronic stress; Cellular proliferation; Adrenal cortex; Pregnancy.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400013
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Chronic stress effects on the apoptotic index of the adrenal cortex of pregnant rats Biocell
Bozzo,Andrea; Soñez,Carlos Alberto; Mugnaini,María Teresa; Pastorino,Isabel Cecilia; Rolando,Alicia Nélida; Romanini,María Cristina; Gauna,Héctor Fernando.
Chronic stress by immobilization during gestation can alter several mechanisms that maintain homeostasis in adrenal gland. The aim of this work was to quantify the apoptotic index of adrenal cortex during mid-pregnancy and to prove cytological characteristics by electron microscopy. The apoptotic index did not present significant differences between the adrenal cortex areas of control and experimental rats in any of the three ages studied. The day of gestation influenced significantly on the apoptotic index in both groups. This index increased as gestation progressed. It may be concluded that chronic stress by immobilization might induce the increase of apoptotic index in adrenal cortex as gestation progresses which might be related variations of plasmatic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic stress; Apoptosis; Adrenal cortex; Pregnancy.
Ano: 2006 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000300004
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The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies BJMBR
Lacroix,A.; N'Diaye,N.; Mircescu,H.; Tremblay,J.; Hamet,P..
Recent studies from several groups have indicated that abnormal or ectopic expression and function of adrenal receptors for various hormones may regulate cortisol production in ACTH-independent hypercortisolism. Gastric inhibitory polypeptide (GIP)-dependent Cushing's syndrome has been described in patients with either unilateral adenoma or bilateral macronodular adrenal hyperplasia; this syndrome results from the large adrenal overexpression of the GIP receptor without any activating mutation. We have conducted a systematic in vivo evaluation of patients with adrenal Cushing's syndrome in order to identify the presence of abnormal hormone receptors. In macronodular adrenal hyperplasia, we have identified, in addition to GIP-dependent Cushing's syndrome,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenal cortex; Cortisol; Cushing's syndrome; Ectopic expression; Hormone receptors.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000010
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