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	Provedor de dados BJMBR (1) Autor Araujo,E.G. (1) Santos,R.C.C. (1) Palavra-chave Amacrine cholinergic cells (1) CAMP (1) Ganglion cell survival (1) Glial cells (1) M1 receptor activity (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2001 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Cyclic AMP increases the survival of ganglion cells in mixed retinal cell cultures in the absence of exogenous neurotrophic molecules, an effect that involves cholinergic activity BJMBR Santos,R.C.C.; Araujo,E.G.. Natural cell death is a well-known degenerative phenomenon occurring during development of the nervous system. The role of trophic molecules produced by target and afferent cells as well as by glial cells has been extensively demonstrated. Literature data demonstrate that cAMP can modulate the survival of neuronal cells. Cultures of mixed retinal cells were treated with forskolin (an activator of the enzyme adenylyl cyclase) for 48 h. The results show that 50 µM forskolin induced a two-fold increase in the survival of retinal ganglion cells (RGCs) in the absence of exogenous trophic factors. This effect was dose dependent and abolished by 1 µM H89 (an inhibitor of protein kinase A), 1.25 µM chelerythrine chloride (an inhibitor of protein kinase C), 50 µM... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ganglion cell survival; CAMP; Amacrine cholinergic cells; M1 receptor activity; Glial cells. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200011 Registros recuperados: 1 Primeira ... 1 ... Última

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