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	Provedor de dados BJM (2) Rev. Microbiol. (1) Autor Debattista,Nora B. (2) Pappano,Nora B. (2) Abou-Shleib,Hamida M (1) Devia,Cristina M. (1) El-Halfawy,Omar M (1) El-Nakeeb,Moustafa A (1) Khalil,Amal M (1) Olivella,Mónica S. (1) Omar,Hoda G (1) Zarelli,Valeria E.P. (1) Mais... Palavra-chave Bacteriostatic activity (3) Antihistaminics (1) Bactericidal activity (1) Chalcone (1) Flavanone (1) Flavone (1) Flavonoids (1) Gram-negative isolates (1) Gram-positive isolates (1) Structure-activity relationship (1) Trihydroxylated chalcones (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2011 (1) 2001 (1) 1998 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Structure-biological activity relationship of synthetic trihydroxilated chalcones Rev. Microbiol. Devia,Cristina M.; Pappano,Nora B.; Debattista,Nora B.. The bacteriostatic activity of 2’,4’,2-trihydroxychalcone; 2’,4’,3-trihydroxychalcone and 2’,4’,4-trihydroxychalcone, prepared by condensation of 2,4-dihydroxyacetophenone and benzaldehyde substituted, against Staphylococcus aureus ATCC 25923 was assayed by agar plate method. The three compounds presented important inhibition halos. In order to elucidate structure-activity relationships, the minimal inhibitory concentrations against S. aureus were determined by the broth dilution method and the results obtained were compared to that of 2',4'-dihydroxychalcone. The sequence observed was: MIC 2’,4’,3-(OH)3 > MIC 2’,4’-(OH)2 > MIC 2’,4’,4-(OH)3 > > MIC 2’,4’,2-(OH)3. These results showed that the introduction of an electron... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bacteriostatic activity; Structure-activity relationship; Flavonoids; Trihydroxylated chalcones. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400014 In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates BJM El-Nakeeb,Moustafa A; Abou-Shleib,Hamida M; Khalil,Amal M; Omar,Hoda G; El-Halfawy,Omar M. Antihistaminics are widely used for various indications during microbial infection. Hence, this paper investigates the antimicrobial activities of 10 antihistaminics belonging to both old and new generations using multiresistant Gram-positive and Gram-negative clinical isolates. The bacteriostatic activity of antihistaminics was investigated by determining their MIC both by broth and agar dilution techniques against 29 bacterial strains. Azelastine, cyproheptadine, mequitazine and promethazine were the most active among the tested drugs. Diphenhydramine and cetirizine possessed weaker activity whereas doxylamine, fexofenadine and loratadine were inactive even at the highest tested concentration (1 mg/ml). The MIC of meclozine could not be determined as it... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antihistaminics; Bactericidal activity; Bacteriostatic activity; Gram-negative isolates; Gram-positive isolates. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000300018 A COMPARATIVE STUDY OF BACTERIOSTATIC ACTIVITY OF SYNTHETIC HYDROXYLATED FLAVONOIDS BJM Olivella,Mónica S.; Zarelli,Valeria E.P.; Pappano,Nora B.; Debattista,Nora B.. Among other properties, flavonoids present a notable bacteriostatic activity. In this paper, minimal inhibitory concentrations (MICs) of 5,7,4'-trihydroxyflavanone (naringenin), 5,7-dihydroxyflavone and 2',4',4- trihydroxychalcone (isoliquitirigenin) against Staphylococcus aureus ATCC 25 923 were determined and compared to values obtained for other chalcones and flavanones previously investigated. Specific growth rates and MICs were determined by a turbidimetric kinetic method. The observed sequence MICflavanone (inactive) >MIC7-hidroxyflavanone (197.6 µgml-1)>MIC5,7,4'-trihydroxyflavanone (120 µgml-1) showed that the introduction of an electron donating group (-OH) causes an increase in bioactivity. On the other hand, the comparisons... Tipo: Info:eu-repo/semantics/article Palavras-chave: Flavanone; Flavone; Chalcone; Bacteriostatic activity. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000300013 Registros recuperados: 3 Primeira ... 1 ... Última

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