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	Provedor de dados BJMBR (1) Genet. Mol. Biol. (1) Autor Brizola,Evelise (1) Dai,Jinhua (1) Félix,Têmis Maria (1) Ge,Zhibin (1) Pinheiro,Bruna (1) Souza,Liliane Todeschini de (1) Vanz,Ana Paula (1) Zambrano,Marina B. (1) Zhang,Haijun (1) Zheng,Xingguo (1) Mais... Palavra-chave Bone fracture (2) Clinical features (1) Compliance (1) MicroRNA-221 (1) Osteoblast differentiation (1) Osteogenesis imperfecta (1) Pamidronate treatment (1) Smad (1) Wnt/Notch (1) ZFPM2 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cyclic pamidronate treatment for osteogenesis imperfecta: Report from a Brazilian reference center Genet. Mol. Biol. Pinheiro,Bruna; Zambrano,Marina B.; Vanz,Ana Paula; Brizola,Evelise; Souza,Liliane Todeschini de; Félix,Têmis Maria. Abstract Treatment of moderate and severe forms of osteogenesis imperfecta (OI) with cyclic pamidronate at the Reference Center for OI Treatment in Southern Brazil was studied. A retrospective cohort study was conducted from 2002 to 2012. Data were obtained during inpatient (drug infusion) and outpatient care. Clinical data, including the presence of blue sclerae, dentinogenesis imperfecta, history and site of the fractures, biochemical data, including calcium, phosphorus, and alkaline phosphatase levels, were systematically collected. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DXA). Forty-five patients (26 females) were included in the study, and the age of the patients at the time of diagnosis ranged from 1 to 144... Tipo: Info:eu-repo/semantics/article Palavras-chave: Osteogenesis imperfecta; Bone fracture; Clinical features; Pamidronate treatment; Compliance. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200252 MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts BJMBR Zheng,Xingguo; Dai,Jinhua; Zhang,Haijun; Ge,Zhibin. Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. The expression levels of miR-221 in the different groups were measured by qRT-PCR. Then, miR-221 mimic and inhibitor were transfected into MC3T3-E1 cells, and cell viability and migration were measured using the CCK-8 assay and the Transwell migration assay. Additionally, the expression levels of differentiation-related factors (Runx2 and Ocn) and ZFPM2 were measured by qRT-PCR. Western blot was used to measure the... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNA-221; Bone fracture; Osteoblast differentiation; ZFPM2; Wnt/Notch; Smad. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200602 Registros recuperados: 2 Primeira ... 1 ... Última

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