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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor GOBIANAND,KUPANNAN (1) Horst,M.A. (1) Jordão Jr.,A.A. (1) KARTHIKEYAN,SIVANESAN (1) Lajolo,F.M. (1) Moreno,F.S. (1) Ong,T.P. (1) PRADEEP,KANNAMPALLI (1) RAJ MOHAN,CHANDRASEKARAN VICTOR (1) Vannucchi,H. (1) Mais... Palavra-chave Diethylnitrosamine (2) Antioxidants (1) Brassica vegetables (1) Cassia fistula (1) Chemoprevention (1) DNA damage (1) Hepatocarcinogenesis (1) Hepatoprotective (1) Lipid peroxidation (1) Silymarin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2010 (2) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats Biol. Res. PRADEEP,KANNAMPALLI; RAJ MOHAN,CHANDRASEKARAN VICTOR; GOBIANAND,KUPANNAN; KARTHIKEYAN,SIVANESAN. Diethylnitrosamine (DEN), found in many commonly consumed foods, is widely reported to induce cancer in animals and humans. The aim of the present study was to investigate the hepatoprotective and antioxidant activities of the leaf extract of the medicinal plant Cassia fistula Linn. against diethylnitrosamine induced liver injury in ethanol pretreated rats. Albino Wistar rats, pretreated with ethanol for 15 days, were administered a single dose of DEN. Thirty days after DEN administration, hepatotocellular damage was observed histologically, along with elevated levels of serum AST, ALT, ALP, LDH, &#947;-GT and bilirubin and a simultaneous fall in the levels of the marker enzymes in the liver tissue. Liver oxidative stress was confirmed by elevated... Tipo: Journal article Palavras-chave: Antioxidants; Cassia fistula; Diethylnitrosamine; Hepatoprotective; Lipid peroxidation; Silymarin. Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100013 Water extracts of cabbage and kale inhibit ex vivo H2O2-induced DNA damage but not rat hepatocarcinogenesis BJMBR Horst,M.A.; Ong,T.P.; Jordão Jr.,A.A.; Vannucchi,H.; Moreno,F.S.; Lajolo,F.M.. The chemopreventive potential of water extracts of the Brassica vegetables cabbage and kale was evaluated by administering their aqueous extracts in drinking water ad libitum to Wistar rats submitted to Ito’s hepatocarcinogenesis model (CB group and K group, respectively - 14 rats per group). Animals submitted to this same model and treated with water were used as controls (W group - 15 rats). Treatment with the vegetable extracts did not inhibit (P > 0.05) placental glutathione S-transferase-positive preneoplastic lesions (PNL). The number of apoptotic bodies did not differ (P > 0.05) among the experimental groups. Ex vivo hydrogen peroxide treatment of rat livers resulted in lower (P < 0.05) DNA strand breakage in cabbage- (107.6 ± 7.8 µm) and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chemoprevention; Hepatocarcinogenesis; Diethylnitrosamine; Brassica vegetables; DNA damage. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300004 Registros recuperados: 2 Primeira ... 1 ... Última

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