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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor CAVIEDES,PABLO (1) CAVIEDES,RAÚL (1) Chen,Xin (1) Dai,Dawei (1) Jiang,Ying (1) Lu,Youming (1) RAPOPORT,STANLEY I (1) Wang,Junyu (1) Yuan,Lei (1) Zhang,Aijun (1) Zou,Dongdong (1) Mais... Palavra-chave Dorsal root ganglion (2) Calcium current (1) Down syndrome (1) MicroRNAs (1) Neuropathic pain (1) Patch clamp (1) Spared nerve injury (1) Tissue culture (1) Trisomy 16 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2019 (1) 2006 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Altered calcium currents in cultured sensory neurons of normal and trisomy 16 mouse fetuses, an animal model for human trisomy 21 (Down Syndrome) Biol. Res. CAVIEDES,PABLO; CAVIEDES,RAÚL; RAPOPORT,STANLEY I. Down syndrome is determined by the presence of an extra copy of autosome 21 and is expressed by multiple abnormalities, with mental retardation being the most striking feature. The condition results in altered electrical membrane properties of fetal dorsal root ganglia (DRG) neurons, as in the trisomy 16 fetal mouse, an animal model of the human condition. Cultured trisomic DRG neurons from human and mouse fetuses present faster rates of depolarization and repolarization in the action potential compared to normal controls and a shorter spike duration. Also, trisomy 16 brain and spinal cord tissue exhibit reduced acetylcholine secretion. Therefore, we decided to study Ca2+ currents in cultured DRG neurons from trisomy 16 and age-matched control mice, using... Tipo: Journal article Palavras-chave: Trisomy 16; Dorsal root ganglion; Calcium current; Tissue culture; Patch clamp; Down syndrome. Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300009 Small RNA sequencing reveals microRNAs related to neuropathic pain in rats BJMBR Dai,Dawei; Wang,Junyu; Jiang,Ying; Yuan,Lei; Lu,Youming; Zhang,Aijun; Zou,Dongdong; Chen,Xin. The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles in the pathogenesis and development process of neuropathic pain. The rat model of neuropathic pain caused by spared nerve injury (SNI) was established in Sprague-Dawley male rats, followed by small RNA sequencing of the L3–L6 dorsal root ganglion. Real-time PCR was performed to validate the differently expressed miRNAs. Functional verification was performed by intrathecally injecting the animals with miRNA agomir. A total of 72 differentially expressed miRNAs were identified in the SNI rats, including 33 upregulated and 39 downregulated miRNAs. The results of qPCR further verified the expression levels of rno-miR-6215... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; Neuropathic pain; Spared nerve injury; Dorsal root ganglion. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000602 Registros recuperados: 2 Primeira ... 1 ... Última

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