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| Pamukcu Baran,Ozlem; Tunik,Selcuk; Akkoc,Hasan; Devieci,Engin; Ayaz,Ercan; Soker,Sevda; Kalkanli Tas,Sevgi; Akkus,Murat. |
| To evaluate histopathologic differences in the thymus of Wistar Albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit-E). VPA (400 mg/kg), FA (400 mcg/kg) and Vit -E (250 mg/kg) were administered to rats on each of gestation days 8, 9 and 10. The fetuses (n:24) were divided into four groups: control, VPA, VPA+Vit-E and VPA+FA groups. On the 20th day of gestation, all pregnant rats were sacrificed and the fetuses were extracted. Thin sections from thymus of live fetuses were stained with uranyl acetate-lead citrate and were examined under transmission electron microscope. The histopathological findings of control group was normal. In VPA group, it showed extensive degenerative changes by VPA were on all tissue... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Fetal thymus; Vitamin E; Folic acid. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400003 |
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