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	Provedor de dados BJMBR (1) Genet. Mol. Biol. (1) Autor Bumbasirevic,Vladimir (1) Chi,Jingwei (1) Chu,Yanchen (1) Fang,Yuan (1) Kravic-Stevovic,Tamara (1) Li,Jing (1) Mimic-Oka,Jasmina (1) Pljesa-Ercegovac,Marija (1) Savic-Radojevic,Ana (1) Simic,Tatiana (1) Wang,Zhijie (1) Zhang,Dongyang (1) Zou,Yunwen (1) Mais... Palavra-chave JNK (2) Anti-tumor (1) Astragalus polysaccharides (1) Co-localization (1) Glutathione S-transferase (1) MicroRNA-133a (1) Osteosarcoma (1) TCC (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Co-localization of GSTP1 and JNK in transitional cell carcinoma of urinary bladder Genet. Mol. Biol. Pljesa-Ercegovac,Marija; Savic-Radojevic,Ana; Kravic-Stevovic,Tamara; Bumbasirevic,Vladimir; Mimic-Oka,Jasmina; Simic,Tatiana. Transitional cell carcinoma (TCC) of urinary bladder belongs to glutathione S-transferase P1 (GSTP1) overexpressing tumors. Upregulated GSTP1 in TCC is related to apoptosis inhibition. This antiapoptotic effects of GSTP1 might be mediated through protein:protein interaction with c-Jun NH2-terminal kinase (JNK). Herein, we analyzed whether a direct link between GSTP1 and JNK exists in TCC. The presence of GSTP1/JNK complexes was analyzed by immunoprecipitation and Western blotting in 20 TCC specimens, obtained after surgery. Co-localization of GSTP1 and JNK was also investigated in the 5637 TCC cell line by immunofluorescence confocal microscopy. By means of immunoprecipitation we show for the first time the presence of GSTP1/JNK complexes in all TCC... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glutathione S-transferase; JNK; TCC; Co-localization. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300013 Astragalus polysaccharides decrease proliferation, migration, and invasion but increase apoptosis of human osteosarcoma cells by up-regulation of microRNA-133a BJMBR Chu,Yanchen; Fang,Yuan; Chi,Jingwei; Li,Jing; Zhang,Dongyang; Zou,Yunwen; Wang,Zhijie. Osteosarcoma (OS) has a high incidence, malignity, and frequency of recurrence and metastasis. In this study, we aimed to explore the potential anti-cancer effects of Astragalus polysaccharides (APS) on human OS MG63 cells as well as underlying mechanisms. Viability of MG63 cells was assessed by CCK-8 assay to determine the adequate concentration of APS. Then, effects of APS on MG63 cell proliferation, cell cycle distribution, apoptosis, and migration and invasion were analyzed by BrdU incorporation, PI staining, flow cytometry, and transwell assays, respectively. The expression levels of proteins involved in these physiological processes were assessed by western blot analysis. Afterwards, miR-133a level in APS-treated cells was determined by qRT-PCR, and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Osteosarcoma; Astragalus polysaccharides; Anti-tumor; MicroRNA-133a; JNK. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200610 Registros recuperados: 2 Primeira ... 1 ... Última

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