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| Registros recuperados: 66 | |
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| Despite evidence that they play similar but independent roles, maternal education and household wealth are usually conflated in studies of the effects of socioeconomic status (SES) on malaria risk. Demographic and Health Survey and Malaria Indicator Survey data from nine countries in sub-Saharan Africa were used to explore the relationship of malaria parasitemia in children with SES factors at individual and cluster scales, controlling for urban/rural residence and other important covariates. In multilevel logistic regression modeling, completion of six years of maternal schooling was associated with significantly lower odds of infection in children (OR = 0.73), as was a household wealth index at the 40th percentile compared to the lowest percentile (OR =... |
| Tipo: Peer-Reviewed Reports |
Palavras-chave: Demographic and Health Survey; DHS; Malaria; Malaria Indicator Survey; Maternal education; MIS; Multilevel modeling; Socioeconomic factors. |
| Ano: 2014 |
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| Fontes,Aparecida Maria; Kashima,Simone; Bonfim-Silva,Ricardo; Azevedo,Rochele; Abraham,Kuruvilla Joseph; Albuquerque,Sérgio Roberto Lopes; Bordin,José Orlando; Langhi Júnior,Dante Mário; Covas,Dimas Tadeu. |
| Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazilian Amazon population; CR1 haplotypes; Knops blood group polymorphism; Malaria. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400002 |
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| Mosnier, Emilie; Dusfour, Isabelle; Lacour, Guillaume; Saldanha, Raphael; Guidez, Amandine; Gomes, Margarete S.; Sanna, Alice; Epelboin, Yanouk; Restrepo, Johana; Davy, Damien; Demar, Magalie; Djossou, Félix; Douine, Maylis; Ardillon, Vanessa; Nacher, Mathieu; Musset, Lise; Roux, Emmanuel. |
| Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017. Methods Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were... |
| Tipo: Text |
Palavras-chave: Plasmodium vivax; Anopheles darlingi; French Guiana; Brazil; Transnational; Outbreak investigation; Indigenous south Americans; Malaria; Amazonia. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00632/74387/74081.pdf |
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| Reyser, Thibaud; To, Tung H.; Egwu, Chinedu; Paloque, Lucie; Nguyen, Michel; Hamouy, Alexandre; Stigliani, Jean-luc; Bijani, Christian; Augereau, Jean-michel; Joly, Jean-patrick; Portela, Julien; Havot, Jeffrey; Marque, Sylvain R. A.; Boissier, Jérôme; Robert, Anne; Benoit-vical, Françoise; Audran, Gérard. |
| Malaria and schistosomiasis are major infectious causes of morbidity and mortality in the tropical and sub-tropical areas. Due to the widespread drug resistance of the parasites, the availability of new efficient and affordable drugs for these endemic pathologies is now a critical public health issue. In this study, we report the design, the synthesis and the preliminary biological evaluation of a series of alkoxyamine derivatives as potential drugs against Plasmodium and Schistosoma parasites. The compounds (RS/SR)-2F, (RR/SS)-2F, and 8F, having IC50 values in nanomolar range against drug-resistant P. falciparum strains, but also five other alkoxyamines, inducing the death of all adult worms of S. mansoni in only 1 h, can be considered as interesting... |
| Tipo: Text |
Palavras-chave: Alkoxyamine; Alkylation; Heme; Malaria; Radical chemistry; Schistosomiasis. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00648/76024/76920.pdf |
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| Trindade,Frances TT; Soares,Ângela A; Moura,Andréa A de; Rego,Tiago B; Soares,Andreimar M; Stábeli,Rodrigo G; Calderon,Leonardo A; Almeida e Silva,Alexandre de. |
| Background Mosquitoes are important vectors of several diseases, including malaria and dengue, and control measures are mostly performed using chemical insecticides. Unfortunately, mosquito resistance to commonly applied insecticides is widespread. Therefore, a prospection for new molecules with insecticidal activity based on Amazon biodiversity using the anuransLeptodactylus knudseni andPhyllomedusa vaillantii was performed against the mosquito speciesAnopheles darlingi and Aedes aegypti.Methods The granular secretion from anuran skin was obtained by manual stimulation, and lethal concentrations (LCs) for larvicidal and adulticidal tests were calculated using concentrations from 1-100 ppm. The skin secretions from the anuran species tested caused... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vector control; Anuran amphibians; Dengue; Malaria. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200334 |
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| Dalla Bona,Ana C; Navarro-Silva,Mário A. |
| We analyzed the reproductive status, ovarian development, daily survival rate, and length of the gonotrophic cycle in females of Anopheles ( Kerteszia ) cruzii Dyar & Knab, to determine how these factors influence the risk of malaria transmission in the coastal region of the state of Paraná, southern Brazil. In the Palmito State Forest, Paranaguá, females were captured at dawn and dusk by aspiration, bimonthly from December 2006 through March 2007. A total of 2,268 females were captured, of which 454 were dissected. Of these, 48% were parous, 50% not reproductive, 73% in Christopher and Mer stages I and II, 23% in stages III to V, 55% nulliparous, 14% uniparous, and 11% had blood in their midgut. Daily survival was 0.24 ± 0.03 overall, 0.51 ± 0.04... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parity; Daily survival rate; Ovarian development; Malaria. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000200021 |
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| Moreira,Luciano A.; Jacobs-Lorena,Marcelo. |
| Malaria kills millions of people every year and the current strategies to control the disease, such as insecticides and drugs have not been completely efficient. Because of that, novel means to fight against malaria are of utmost importance. Advances in the study of the mosquito vector and its interactions with the malaria parasite made scientists think that it is possible to genetically manipulate the mosquitoes to make them inefficient vectors. Here we review the advances on the introduction of foreign genes into the mosquito germ line, the characterization of tissue-specific promoters, the identification of gene products that block development of the parasite in the mosquito, and we discuss the recent generation of transgenic mosquitoes impaired for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Malaria; Transgenesis; Transmission blocking; Plasmodium. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000400001 |
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| Arias,Lida; Bejarano,Eduar E.; Márquez,Edna; Moncada,John; Vélez,Iván; Uribe,Sandra. |
| Studies of insect vectors may be facilitated by using laboratory colonies. However, it has been suggested that the colony insects are not representative of natural populations, sometimes yealding to erroneous interpretations of the intraspecific genetic variation between the individuals. In the present study the variability of the mitochondrial gene cytochrome b was evaluated among a closed laboratory colony of Anopheles albimanus that was founded 20 years ago and the field population from which it was derived. The analyses revealed the presence of five and three nucleotide haplotypes in the wild and colony populations, respectively. Wild individuals presented greater variability than those of the colony based on the number of polymorphic sites, haplotype... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genetic variability; Malaria; Mosquito. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2005000300020 |
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| Taylor-Robinson, Andrew W.; Heal, Karen G.. |
| Malaria is the world's most important parasitic disease, imposing a massive health burden on people living in the tropics, often in the poorest countries. The vast majority of deaths in humans from malaria are caused by one species of the hemoprotozoan, Plasmodium falciparum., against which effective control measures are urgently needed. The global situation has deteriorated in recent times due to increased resistance of the anopheline mosquitoes that transmit P. falciparum to insecticides, and of the parasites themselves to drug therapy. An efficacious and cost-effective vaccine against this parasite is considered a public health priority. A vaccine that targets pre-erythrocytic parasites in the liver could potentially prevent clinical disease by blocking... |
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Palavras-chave: Malaria; Plasmodium falciparum; Liver stage; Vaccine; Cellular immunity. |
| Ano: 2001 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/133 |
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| Kume, Aiko; Dang Trinh Minh Anh; Shichiri, Mototada; Ishida, Noriko; Suzuki, Hiroshi. |
| Background: Artemisinin-based combination therapy (ACT) has been adopted as national policy for the first-line treatment in large number of malaria-endemic regions. However, artemisinin-resistant parasites have emerged and are spreading, with slow-cleaning parasites being reported in patients treated with ACT. It means that more parasites are exposed to the partner drug alone and the risk of developing resistant parasites against the partner drug is increasing. Therefore, the development of a new method to enhance the effect of artemisinin is required. In this study, the potential effect of probucol as a combination drug of dihydroartemisinin (DHA), an artemisinin derivative, was examined. Methods: C57BL/6 J mice infected with Plasmodium yoelii XL-17 were... |
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Palavras-chave: C57BL/6 J mice; Dihydroartemisinin; Malaria; Oxidative stress; Probucol; Plasmodium yoelii XL-17; Vitamin E. |
| Ano: 2016 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4436 |
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| HERBAS, Maria Shirley; SUZUKI, Hiroshi; 鈴木, 宏志. |
| Nutritional deficiencies are frequent in malaria-endemic areas. It seems that micronutrient antioxidants play an important role in malaria parasite’s proliferation. Thus, the effect of vitamin C deficiency on malaria infection was examined in mice. When vitamin C deficient mice, L-gulono-γ-lactone oxidase gene knockout mice which are unable to synthesize ascorbic acid, were infected with a lethal dose of Plasmodium berghei NK65-infected red blood cells, the knockout mice showed similar parasitemia kinetics and survival rates as wild-type mice. The results indicate that deficiency of vitamin C might not affect the development of the malaria parasite in mice. |
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Palavras-chave: Free radical; Malaria; Vitamin C. |
| Ano: 2010 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3016 |
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| Rzepczyk, C. M.; Anderson, K. L.; Crurshes, P. A.; Baxter, E. P.; Kere, N.; Irving, D.; Dyer, S.; Jones, G. L.. |
| Merozoite surface antigen 2 (MSA2) is a Plasmodium falciparum vaccine candidate. Antibody responses to MSA2 in Melanesians naturally exposed to P. falciparum were investigated by ELISA using the recombinant MSA2 protein known as Ag 1609 and 65 overlapping synthetic peptides spanning predominantly the conserved N and C terminal regions of MSA2. Significant differences were obtained between control and malaria exposed subjects in the ability of sera to bind to Ag 1609. The median absorbance obtained with control sera was 0.36 whereas that obtained with sera from malaria exposed subjects was 1.8. The sera of ninety-five percent of malaria exposed subjects reacted significantly with Ag 1609. The percentage reactivity of the control sera with Ag 1609 was 39%.... |
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Palavras-chave: Malaria; Merozoite surface antigen 2 (MSA2); Antibody. |
| Ano: 1992 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/170 |
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| Abila, R.O.; Omwega, R.N.; Lwenya, C.. |
| Fishing is known to be one of the oldest occupations of mankind and in Lake Victoria (Kenya); it has been largely practiced at artisanal levels. Despite this, poverty amongst the fisher folk remains high. Why the fisher folk remain in perpetual poverty was the key research question for this study. Sampling was conducted on 12 landing beaches between June and August 2004. Data was obtained using survey questionnaires; personal interviews were made using open-ended questions and beach observations. Results from this study indicates that 179 fishers sampled earned an average income of Ksh. 107,063 each in a year with modal income of Ksh. 57,600 while in a day they earned an average income of Ksh. 518 each with modal income of Ksh. 200. Fishers perceived that... |
| Tipo: Proceedings Paper |
Palavras-chave: Fishing; Artisanal fishing; Lake fisheries; Socioeconomic aspects; Fishery economics; Public health; Malaria; Fishery management; Pricing. |
| Ano: 2006 |
URL: http://hdl.handle.net/1834/1495 |
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| Registros recuperados: 66 | |
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