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	Provedor de dados Anais da ABC (AABC) (1) BJID (1) BJMBR (1) Rev. Microbiol. (1) Autor ALVES,LETÍCIA S. (1) ASSUNÇÃO-MIRANDA,IRANAIA (1) Barbosa,Joel Antonio (1) CAMPOS,HOLMES S. (1) CAVALHEIRO,MARIANA G. (1) COSTA,LEANDRO SILVA DA (1) Esposito,Danillo Lucas Alves (1) Fonseca,Benedito Antonio Lopes da (1) Ishimaru,D. (1) Marcicano,F.G.P. (1) POIAN,ANDREA T. DA (1) Rebello,M.A. (1) Rebello,Moacyr Alcoforado (1) Mais... Palavra-chave Mayaro virus (4) Actinomycin D (1) Aedes albopictus cells (1) Alphavirus (1) Alphaviruses (1) Chikungunya virus (1) Epidemiology (1) Heat-shock proteins (1) Macrophage activation (1) Outbreaks (1) Prostaglandin (1) Prostaglandins (1) Protein synthesis (1) Reactive oxygen species (1) Vero cells (1) Viral arthritis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2017 (1) 2016 (1) 1998 (2) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última INHIBITION OF MAYARO VIRUS REPLICATION BY PROSTAGLANDIN A1 IN Aedes albopictus CELLS Rev. Microbiol. Barbosa,Joel Antonio; Rebello,Moacyr Alcoforado. Prostaglandin A1 (PGA1) inhibits Mayaro virus replication in Aedes albopictus cells at nontoxic doses to uninfected cells. At 10 µg/ml, PGA1 decreases virus production by 90%. The presence of PGA1 during virus adsorption, with no treatment after infection, reduces virus yield by 41%. Antiviral activity is observed even when treatment starts at one or two hours post-infection. However, in cells pre-treated with PGA1 during 24 hours, virus replication is not impaired. Thus, events ocurring during initial stages of infection and after virus adsorption and penetration must be the target of PGA1 action. SDS-PAGE analysis of 35S-methionine labelled proteins shows that PGA1 inhibits the synthesis of viral proteins and induces the synthesis of polypeptides with... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mayaro virus; Prostaglandin; Aedes albopictus cells; Heat-shock proteins; Actinomycin D. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000300013 Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication Anais da ABC (AABC) CAVALHEIRO,MARIANA G.; COSTA,LEANDRO SILVA DA; CAMPOS,HOLMES S.; ALVES,LETÍCIA S.; ASSUNÇÃO-MIRANDA,IRANAIA; POIAN,ANDREA T. DA. ABSTRACT Alphaviruses among the viruses that cause arthritis, consisting in a public health problem worldwide by causing localized outbreaks, as well as large epidemics in humans. Interestingly, while the Old World alphaviruses are arthritogenic, the New World alphaviruses cause encephalitis. One exception is Mayaro virus (MAYV), which circulates exclusively in South America but causes arthralgia and is phylogenetically related to the Old World alphaviruses. Although MAYV-induced arthritis in humans is well documented, the molecular and cellular factors that contribute to its pathogenesis are completely unknown. In this study, we demonstrated for the first time that macrophages, key players in arthritis development, are target cells for MAYV infection,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Alphaviruses; Mayaro virus; Macrophage activation; Reactive oxygen species; Viral arthritis. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401485 Will Mayaro virus be responsible for the next outbreak of an arthropod-borne virus in Brazil? BJID Esposito,Danillo Lucas Alves; Fonseca,Benedito Antonio Lopes da. Abstract Mayaro virus is an alphavirus from the Togaviridae family and is transmitted mainly by Hemagogus mosquitoes. This virus circulates in high-density tropical forests or rural areas of Central and South America causing a disease characterized by high-grade fever, maculopapular skin rash and marked arthralgia that, in some patients, can persist for long periods after infection and may be misinterpreted as chikungunya. Although only a few outbreaks involving this virus have been reported, in the last years the number of Mayaro virus infections has increased in the central and northern regions of Brazil. In this review, we describe the reported prevalence of this infection over the years and discuss the circumstances that can contribute to the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mayaro virus; Alphavirus; Chikungunya virus; Epidemiology; Outbreaks. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500540 Inhibition of Mayaro virus replication by prostaglandin A1 and B2 in Vero cells BJMBR Ishimaru,D.; Marcicano,F.G.P.; Rebello,M.A.. The effect of prostaglandins (PGA1 and PGB2) on the replication of Mayaro virus was studied in Vero cells. PGA1 and PGB2 antiviral activity was found to be dose-dependent. However, while 10 µg/ml PGB2 inhibited virus yield by 60%, at the same dose PGA1 suppressed virus replication by more than 90%. SDS-PAGE analysis of [35S]-methionine-labelled proteins showed that PGA1 did not alter cellular protein synthesis. In infected cells, PGA1 slightly inhibited the synthesis of protein C, while drastically inhibiting the synthesis of glycoproteins E1 and E2. Tipo: Info:eu-repo/semantics/other Palavras-chave: Prostaglandins; Mayaro virus; Vero cells; Protein synthesis. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900003 Registros recuperados: 4 Primeira ... 1 ... Última

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