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| Abdoon,N. A.; Ali,A. A.; Alnema,A. A.; Hag-Ali,M.; Fatani,A. J.. |
| The cumulative actions of scorpion neurotoxins are complex and may be traced to activation of different ion channels with subsequent release of various transmitters and modulators including inflammatory mediators. This could lead to various pathological manifestations such as acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), and multiple organ failure (MOF). Several approaches have been advocated to treat the multitude of scorpion-venom-elicited pathological changes. However, few have tried to combat the venom-induced effects on the inflammatory process, which manifest as ARDS, SIDS and MOF. Thus, the aim of this study was to determine the capability of inhibitors of different steps of the inflammatory sequence of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leiurus quinquestriatus quinquestriatus; Scorpion venom; Acute respiratory distress syndrome; Systemic inflammatory response syndrome; Multiple organ failure; Montelukast; Hydrocortisone; Indomethacin. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300003 |
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| Fleck,J.; Temp,F.R.; Marafiga,J.R.; Jesse,A.C.; Milanesi,L.H.; Rambo,L.M.; Mello,C.F.. |
| Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phenobarbital, were able to reduce seizures in PTZ-kindled mice and alter CysLT receptor expression. Montelukast (10 mg/kg, sc) and phenobarbital (20 mg/kg, sc) increased the latency to generalized seizures in kindled mice. Montelukast increased CysLT1immunoreactivity only in non-kindled, PTZ-challenged mice. Interestingly, PTZ challenge decreased CysLT2 immunoreactivity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Montelukast; CysLT1R; CysLT2R; Seizure; PTZ; Kindling. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400602 |
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