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| Gui,Qifeng; Yang,Yunmei; Zhang,Jiajia. |
| ABSTRACT This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups: a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for <1 month prior to admission. A multivariate logistic regression analysis was performed to identify risk and protective factors for severe sepsis. A significantly lower incidence of organ dysfunction was found in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mortality; Organ dysfunction; Older adults; Sepsis; Statins. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300255 |
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| Costa,Ramon Teixeira; Araújo,Orlei Ribeiro de; Brunialti,Milena Karina Coló; Assunção,Murilo Santucci Cesar; Azevedo,Luciano César Pontes; Freitas,Flávio; Salomão,Reinaldo. |
| ABSTRACT Objective: We evaluated the kinetics of cytokines belonging to the T helper1 (Th1), Th2, and Th17 profiles in septic patients, and their correlations with organ dysfunction and hospital mortality. Methods: This was a prospective observational study in a cohort of septic patients admitted to the intensive care units (ICU) of three Brazilian general hospitals. A total of 104 septic patients and 53 health volunteers (controls) were included. Plasma samples were collected within the first 48 h of organ dysfunction or septic shock (0D), after seven (D7) and 14 days (D14) of follow-up. The following cytokines were measured by flow cytometry: Interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10, IL-12/23p40, IL-17, IL-21, tumor necrosis factor-α (TNF-α),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Cytokines; Th response; Organ dysfunction; SOFA. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200079 |
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