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Analysis of different levels of positive end-expiratory pressure during lung retrieval for transplantation: an experimental study BJMBR
Gonçalves-Ferri,W.A.; Jauregui,A.; Martins-Celini,F.P.; Sansano,I.; Fabro,A.T.; Sacramento,E.M.F.; Aragon,D.C.; Ochoa,J.M..
Atelectasis and inadequate oxygenation in lung donors is a common problem during the retrieval of these organs. Nevertheless, the use of high positive end-expiratory pressure (PEEP) is not habitual during procedures of lung retrieval. Twenty-one Sprague-Dawley male consanguineous rats were used in the study. The animals were divided into 3 groups according to the level of PEEP used: low (2 cmH2O), moderate (5 cmH2O), and high (10 cmH2O). Animals were ventilated with a tidal volume of 6 mL/kg. Before lung removal, the lungs were inspected for the presence of atelectasis. When atelectasis was detected, alveolar recruitment maneuvers were performed. Blood gasometric analysis was performed immediately. Finally, the lungs were retrieved, weighed, and submitted...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anesthesia; Lung transplantation; Mechanical ventilation; Pulmonary recruitment; PEEP.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000700607
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Variable positive end-expiratory pressure can maintain oxygenation in experimental acute respiratory distress syndrome induced by oleic acid in dogs BJMBR
Lanza,F.C.; Damasceno,M.C.P.; Leme,F.; Yagui,A.C.Z.; Paiva,K.C.; Luque,A.; Beppu,O.S..
The use of positive end-expiratory pressure (PEEP) or lung recruitment maneuvers (RM) to improve oxygenation in acute respiratory distress syndrome (ARDS) is used but it may reduce cardiac output (CO). Intermittent PEEP may avoid these complications. Our objective was to determine if variable PEEP compared with constant PEEP is capable of maintaining arterial oxygenation and minimizing hemodynamic alterations with or without RM. Eighteen dogs with ARDS induced by oleic acid were randomized into three equal groups: group 1, low variable PEEP; group 2, high variable PEEP, and group 3, RM + high variable PEEP. All groups were submitted to constant PEEP, followed by variable PEEP (PEEP was increased from 5 to 10 cmH2O in group 1, and from 5 to 18 cmH2O in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute respiratory distress syndrome (ARDS); PEEP; Mechanical ventilation; Oleic acid.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000800007
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The effects of positive end-expiratory pressure on respiratory system mechanics and hemodynamics in postoperative cardiac surgery patients BJMBR
Auler Jr.,J.O.C.; Carmona,M.J.C.; Barbas,C.V.; Saldiva,P.H.N.; Malbouisson,L.M.S..
We prospectively evaluated the effects of positive end-expiratory pressure (PEEP) on the respiratory mechanical properties and hemodynamics of 10 postoperative adult cardiac patients undergoing mechanical ventilation while still anesthetized and paralyzed. The respiratory mechanics was evaluated by the inflation inspiratory occlusion method and hemodynamics by conventional methods. Each patient was randomized to a different level of PEEP (5, 10 and 15 cmH2O), while zero end-expiratory pressure (ZEEP) was established as control. PEEP of 15-min duration was applied at 20-min intervals. The frequency dependence of resistance and the viscoelastic properties and elastance of the respiratory system were evaluated together with hemodynamic and respiratory...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Postoperative cardiac surgery; PEEP; Respiratory mechanics; Hemodynamics.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100005
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