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Hawthorn (Crataegus Oxyacantha) Extract in the Drinking Water of Broilers on Growth and Incidence of Pulmonary Hypertension Syndrome (PHS) Rev. Bras. Ciênc. Avic.
Ahmadipour,B; Kalantar,M; Hosseini,SM; Yang,LG; Kalantar,MH; Raza,SHA; Schreurs,NM.
ABSTRACT Hawthorn extract has been used for ameliorating cardiac disorders and pulmonary hypertension. Flavonoids and oligomeric proanthocyanidins are considered to be responsible for the positive health effects of hawthorn extract. The effect of Hawthorn extract in the water supply on feed intake, growth, carcass traits, internal organ weight, cardiac indices, the concentration of serum proteins and the incidence of pulmonary hypertension syndrome was evaluated in broiler chickens. At one day-of-age, 225 chickens were assigned to one of three experimental groups where 0, 0.1 and 0.2 ML of hawthorn extract was added per one liter of drinking water. Feed intake, live weight gain and carcass weight increased when hawthorn extract was included in the drinking...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chicken; Growth; Hawthorn; Pulmonary hypertension; Ascites.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000400639
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Strategies to alleviate the incidence of ascites in broilers: a review Rev. Bras. Ciênc. Avic.
Aftab,U; Khan,AA.
Ascites is a complex problem caused by many interacting factors such as genetics, environment and management. Many nutritional, medicinal and management strategies have been proposed to alleviate the problem. Higher levels of dietary vitamin C and E along with selenium yeast might be beneficial, presumably because of their role in improving cellular integrity. Oils rich in n-3 fatty acids have been shown to reduce pulmonary hypertension and, consequently, ascites incidence. The potential use of flax oil has already been demonstrated, whereas the effects of other oils rich in n-3 fatty acids (fish, linseed and canola oils) remain to be investigated. The assessment of the effects of dietary electrolyte balance on ascites incidence seems to be a promising...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ascites; Broilers; Pulmonary hypertension.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2005000400001
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Effect of pulmonary hypertension on outcome of pulmonary tuberculosis BJID
Marjani,Majid; Baghaei,Parvaneh; Malekmohammad,Majid; Tabarsi,Payam; Sharif-Kashani,Babak; Behzadnia,Neda; Mansouri,Davood; Masjedi,Mohammad Reza; Velayati,Ali Akbar.
Background:This study performed at the National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran, aimed to evaluate the effect of concomitant pulmonary hypertension on the outcome of pulmonary tuberculosis.Methods:New cases of pulmonary tuberculosis were recruited for the study. Pulmonary hypertension was defined as systolic pulmonary arterial pressure ≥35 mm Hg estimated by transthoracic Doppler echocardiography. We assessed the relationship between pulmonary hypertension and mortality during the six-month treatment of tuberculosis.Results:Of 777 new cases of pulmonary tuberculosis, 74 (9.5%) had systolic pulmonary arterial pressure ≥35 mm Hg. Ten of them (13.5%) died during treatment compared to 5% of cases with pulmonary arterial...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; Pulmonary hypertension; Echocardiography; Survival.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500487
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Herpes simplex type 2 pneumonia BJID
Calore,Edenilson Eduardo.
Extensive reviews of pulmonary infections in AIDS have reported few herpetic infections. Generally these infections are due to Herpes simplex type 1. Pneumonia due to herpes type 2 is extremely rare. We describe a 40 year-old HIV positive woman who complained of fever, cough and dyspnea for seven years. She had signs of heart failure and the appearance of her genital vesicles was highly suggestive of genital herpes. Echocardiography showed marked pulmonary hypertension, right ventricular hypertrophy and tricuspid insufficiency. After a few days of hospitalization she was treated with Aciclovir and later with Ganciclovir. An open pulmonary biopsy revealed an interstitial inflammation, localized in the alveolar walls. Some pulmonary arteries had widened...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Herpes pneumonia; AIDS; Opportunistic infections; Pulmonary hypertension; Herpes simplex.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600006
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Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension BJMBR
Fu,L.C.; Lv,Y.; Zhong,Y.; He,Q.; Liu,X.; Du,L.Z..
Intrauterine growth retardation (IUGR) is associated with the development of adult-onset diseases, including pulmonary hypertension. However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular dysfunction later in life is not fully understood. Here, we investigated the role of tyrosine phosphorylation of voltage-gated potassium channel 1.5 (Kv1.5) in this prenatal event that results in exaggerated adult vascular dysfunction. A rat model of chronic hypoxia (2 weeks of hypoxia at 12 weeks old) following IUGR was used to investigate the physiological and structural effect of intrauterine malnutrition on the pulmonary artery by evaluating pulmonary artery systolic pressure and vascular diameter in male rats. Kv1.5...
Tipo: Info:eu-repo/semantics/article Palavras-chave: IUGR; Kv1.5; PASMCs; Pulmonary hypertension; Tyrosine phosphorylation.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100604
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Sildenafil prevents the increase of extravascular lung water and pulmonary hypertension after meconium aspiration in newborn piglets BJMBR
Silvera,F.E.; Blasina,M.F.; Vaamonde,L.; Tellechea,S.; Godoy,C.; Zabala,S.; Mañana,G.; Martell,M.; Olivera,W..
Meconium aspiration syndrome causes respiratory failure after birth and in vivo monitoring of pulmonary edema is difficult. The objective of the present study was to assess hemodynamic changes and edema measured by transcardiopulmonary thermodilution in low weight newborn piglets. Additionally, the effect of early administration of sildenafil (2 mg/kg vo, 30 min after meconium aspiration) on this critical parameter was determined in the meconium aspiration syndrome model. Thirty-eight mechanically ventilated anesthetized male piglets (Sus scrofa domestica) aged 12 to 72 h (1660 ± 192 g) received diluted fresh human meconium in the airway in order to evoke pulmonary hypertension (PHT). Extravascular lung water was measured in vivo with a PiCCO monitor and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lung water; Meconium aspiration syndrome; Newborn; Sildenafil; Pulmonary hypertension.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000800007
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One-year follow-up of the effects of sildenafil on pulmonary arterial hypertension and veno-occlusive disease BJMBR
Barreto,A.C.; Franchi,S.M.; Castro,C.R.P.; Lopes,A.A..
We hypothesized that chronic oral administration of the phosphodiesterase-5 inhibitor sildenafil could improve the exercise capacity and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) on the basis of previous short-term studies. We tested this hypothesis in 14 subjects with PAH, including seven patients with the idiopathic form and seven patients with atrial septal defects, but no other congenital heart abnormalities. Patients were subjected to a 6-min walk test and dyspnea was graded according to the Borg scale. Pulmonary flow and pressures were measured by Doppler echocardiography. Patients were given sildenafil, 75 mg orally three times a day, and followed up for 1 year. Sildenafil therapy resulted in the following...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sildenafil; Pulmonary hypertension; Pulmonary veno-occlusive disease; Phosphodiesterase inhibitors.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200006
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Angiotensin II type 1 receptor blockade partially attenuates hypoxia-induced pulmonary hypertension in newborn piglets: relationship with the nitrergic system BJMBR
Camelo Jr.,J.S.; Martins,A.R.; Rosa,E.; Ramos,S.G.; Hehre,D.; Bancalari,E.; Suguihara,C..
The objective of this study was to observe possible interactions between the renin-angiotensin and nitrergic systems in chronic hypoxia-induced pulmonary hypertension in newborn piglets. Thirteen chronically instrumented newborn piglets (6.3 ± 0.9 days; 2369 ± 491 g) were randomly assigned to receive saline (placebo, P) or the AT1 receptor (AT1-R) blocker L-158,809 (L) during 6 days of hypoxia (FiO2 = 0.12). During hypoxia, pulmonary arterial pressure (Ppa; P < 0.0001), pulmonary vascular resistance (PVR; P < 0.02) and the pulmonary to systemic vascular resistance ratio (PVR/SVR; P < 0.05) were significantly attenuated in the L (N = 7) group compared to the P group (N = 6). Western blot analysis of lung proteins showed a significant decrease of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Newborn animals; Pulmonary hypertension; Angiotensin II; Angiotensin receptors; Hypoxia.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200012
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A mathematical framework for group analysis of von Willebrand factor multimeric composition following luminography BJMBR
Lopes,A.A.; Soares,R.P.S.; Maeda,N.Y..
The objective of the present study was to establish a method for quantitative analysis of von Willebrand factor (vWF) multimeric composition using a mathematical framework based on curve fitting. Plasma vWF multimers from 15 healthy subjects and 13 patients with advanced pulmonary vascular disease were analyzed by Western immunoblotting followed by luminography. Quantitative analysis of luminographs was carried out by calculating the relative densities of low, intermediate and high molecular weight fractions using laser densitometry. For each densitometric peak (representing a given fraction of vWF multimers) a mean area value was obtained using data from all group subjects (patients and normal individuals) and plotted against the distance between the peak...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Von Willebrand factor; Luminography; Densitometry; Curve fitting; Pulmonary hypertension.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100002
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Inactivated Pseudomonas aeruginosa inhibits hypoxia-induced pulmonary hypertension by preventing TGF-β1/Smad signaling BJMBR
Chai,S.D.; Liu,T.; Dong,M.F.; Li,Z.K.; Tang,P.Z.; Wang,J.T.; Ma,S.J..
Pseudomonas aeruginosa is one of the common colonizing bacteria of the human body and is an opportunistic pathogen frequently associated with respiratory infections. Inactivated P. aeruginosa (IPA) have a variety of biological effects against inflammation and allergy. Transforming growth factor-β (TGF-β) signaling plays a critical role in the regulation of cell growth, differentiation, and development in a wide range of biological systems. The present study was designed to investigate the effects of IPA on TGF-β/Smad signaling in vivo, using a hypoxia-induced pulmonary hypertension (PH) rat model. Sprague Dawley rats (n=40) were exposed to 10% oxygen for 21 days to induce PH. At the same time, IPA was administered intravenously from day 1 to day 14. Mean...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Inactivated Pseudomonas aeruginosa; Pulmonary hypertension; TGF-β/Smad; Primary arterial smooth muscle cells; Α-smooth muscle actin.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000601
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Plasma von Willebrand factor as a predictor of survival in pulmonary arterial hypertension associated with congenital heart disease BJMBR
Lopes,A.A.; Barreto,A.C.; Maeda,N.Y.; Cícero,C.; Soares,R.P.S.; Bydlowski,S.P.; Rich,S..
Biomarkers have been identified for pulmonary arterial hypertension, but are less well defined for specific etiologies such as congenital heart disease-associated pulmonary arterial hypertension (CHDPAH). We measured plasma levels of eight microvascular dysfunction markers in CHDPAH, and tested for associations with survival. A cohort of 46 inoperable CHDPAH patients (age 15.0 to 60.2 years, median 33.5 years, female:male 29:17) was prospectively followed for 0.7 to 4.0 years (median 3.6 years). Plasma levels of von Willebrand factor antigen (VWF:Ag), tissue plasminogen activator (t-PA) and its inhibitor (PAI-1), P-selectin, reactive C-protein, tumor necrosis factor alpha, and interleukin-6 and -10 were measured at baseline, and at 30, 90, and 180 days in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pulmonary hypertension; Congenital heart disease; Eisenmenger syndrome; Endothelial dysfunction; Von Willebrand factor; Th2 cytokine response.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200011
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Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis BJMBR
Zeng,Y.; Yang,D.D.; Feng,S.; Shen,H.Y.; Wang,Z.; Jiang,S.; Shi,Y.B.; Fu,J.X..
We investigated the risk factors for pulmonary hypertension (PH) in patients receiving maintenance peritoneal dialysis (MPD). A group of 180 end-stage renal disease patients (124 men and 56 women; mean age: 56.43±8.36) were enrolled in our study, which was conducted between January 2009 and June 2014. All of the patients received MPD treatment in the Dialysis Center of the Second Affiliated Hospital of Soochow University. Clinical data, laboratory indices, and echocardiographic data from these patients were collected, and follow-ups were scheduled bi-monthly. The incidence and relevant risk factors of PH were analyzed. The differences in measurement data were compared by t-test and enumeration data were compared with the χ2 test. Among the 180 patients...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Maintenance peritoneal dialysis; Pulmonary hypertension; End-stage renal disease; Internal arteriovenous fistula; Hypertensive nephropathy; Ejection fraction.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300703
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Pulmonary hypertension due to acute respiratory distress syndrome BJMBR
Ñamendys-Silva,S.A.; Santos-Martínez,L.E.; Pulido,T.; Rivero-Sigarroa,E.; Baltazar-Torres,J.A.; Domínguez-Cherit,G.; Sandoval,J..
Our aims were to describe the prevalence of pulmonary hypertension in patients with acute respiratory distress syndrome (ARDS), to characterize their hemodynamic cardiopulmonary profiles, and to correlate these parameters with outcome. All consecutive patients over 16 years of age who were in the intensive care unit with a diagnosis of ARDS and an in situ pulmonary artery catheter for hemodynamic monitoring were studied. Pulmonary hypertension was diagnosed when the mean pulmonary artery pressure was >25 mmHg at rest with a pulmonary artery occlusion pressure or left atrial pressure <15 mmHg. During the study period, 30 of 402 critically ill patients (7.46%) who were admitted to the ICU fulfilled the criteria for ARDS. Of the 30 patients with ARDS,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pulmonary hypertension; Acute respiratory distress syndrome; Pulmonary artery catheter; Intensive care unit.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001000904
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Umbilical cord blood and neonatal endothelin-1 levels in preterm newborns with and without respiratory distress syndrome BJMBR
Benjamin,A.C.W.; Silveira,R.C.; Procianoy,R.S..
Increased pulmonary vascular resistance in preterm newborn infants with respiratory distress syndrome is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns. We determined umbilical cord blood and neonatal (second sample) levels of endothelin-1 in 18 preterm newborns with respiratory distress syndrome who had no clinical or echocardiographic diagnosis of pulmonary hypertension and 22 without respiratory distress syndrome (gestational ages: 31.4 ± 1.6 and 29.3 ± 2.3 weeks, respectively). Umbilical cord blood and a second blood sample taken 18 to 40 h after birth were used for endothelin-1 determination by enzyme immunoassay. Median umbilical cord blood endothelin-1 levels were similar in both groups (control:...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Endothelin-1; Respiratory distress syndrome; Prematurity; Hyaline membrane disease; Pulmonary hypertension; SNAPPE II.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900017
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Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study BJMBR
Barreto,A.C.; Maeda,N.Y.; Soares,R.P.S.; Cícero,C.; Lopes,A.A..
We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH). Sixty patients, aged 13 to 60 years, with idiopathic (N = 14) or congenital heart disease-associated PAH (N = 46) were equally but randomly assigned to rosuvastatin treatment (10 mg a day, orally) or placebo for 6 months in a blind fashion. Plasma levels of P-selectin, tissue-plasminogen activator and its inhibitor as well as von Willebrand factor antigen were measured by enzyme-linked immunoassay before and after 1, 3, and 6 months of treatment. Baseline levels of biomarkers were elevated (68, 16, 45 and 46% increase relative to controls, for P-selectin, von...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pulmonary hypertension; Statins; Endothelial dysfunction; P-selectin; Tissue-plasminogen activator and inhibitor; Von Willebrand factor.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800003
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