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| Registros recuperados: 95 | |
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| Teixeira,Santuza M.; Paiva,Rita Márcia Cardoso de; Kangussu-Marcolino,Monica M.; DaRocha,Wanderson D.. |
| In 2005, draft sequences of the genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, also known as the Tri-Tryp genomes, were published. These protozoan parasites are the causative agents of three distinct insect-borne diseases, namely sleeping sickness, Chagas disease and leishmaniasis, all with a worldwide distribution. Despite the large estimated evolutionary distance among them, a conserved core of ~6,200 trypanosomatid genes was found among the Tri-Tryp genomes. Extensive analysis of these genomic sequences has greatly increased our understanding of the biology of these parasites and their host-parasite interactions. In this article, we review the recent advances in the comparative genomics of these three species. This analysis also... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trypanosoma brucei; Trypanosoma cruzi; Leishmania major; Genome; RNAseq. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100001 |
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| Albuquerque,Sergio de; Lopes,Ruberval Armando; Sala,Miguel Angel; Abraháo,Ana Amelia Carraro; Ribeiro,Rosa Domingues. |
| Fueron estudiadas las alteraciones y el nivel de deterioro de las parótidas de animales infectados con la cepa RAL de Trypanosoma cruzi. Se utilizaron ratones albinos (Mus musculus) de ambos sexos, debido al dimorfismo sexual de las glándulas salivares, inoculados con 2 x 10(4) tripomastigotes sanguíneos de la cepa RAL del T. cruzi. Los animales fueron sacrificados al 12° día de infección, coincidiendo con el pico parasitémico. La parótida fue procesada histológicamente y, posteriormente, evaluada histopatológica y morfometricamente. Los resultados permitieron verificar intenso parasitismo en la glándula, la que presentó desorganización estructural y atrofia generalizada de acinos y conductos, más intensos en las hembras. Concluyendo, la cepa RAL del T.... |
| Tipo: Journal article |
Palavras-chave: Trypanosoma cruzi; Cepa RAL; Ratón; Parótida; Histopatología; Morfometría. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200004 |
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| Ragonha,Louise Helena Olhan; Abrahão,Ana Amélia Carraro; Sala,Miguel Angel; Lopes,Ruberval A.; Ribeiro,Rosa Domingues; Prado Jr.,José Clovis do; Albuquerque,Sérgio de; Zucoloto,Sérgio. |
| El objetivo de este trabajo fue caracterizar histopatológicamente y morfométricamente las alteraciones del tejido hepático de ratón, durante la fase aguda de la infección por la cepa MORC-2 de Trypanosoma cruzi. Esta cepa mostró acentuado tropismo por el hígado, con numerosos nidos de amastigotes en los cortes examinados. El hígado de los animales infectados estaba constituido por células menores, con citoplasma granuloso. En algunas áreas, los sinusoides estaban congestionados y las células de Kupffer hipertróficas e hiperplásicas. El tejido hepático mostró focos circunscritos de células inflamatorias en áreas de necrosis, sinusoides, en torno de las venas centrolobulillares y de los espacios porta. La vena centrolobulillar estaba dilatada y... |
| Tipo: Journal article |
Palavras-chave: Morfometría; Histopatología; Hígado; Ratón; Trypanosoma cruzi; Cepa MORC-2. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400015 |
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| Sala,Miguel Ángel; Lopes,Ruberval Armando; Abrahão,Ana Amelia Carraro; Meneguette,Cicero; Albuquerque,Sérgio de; Ribeiro,Rosa Domingues. |
| El objetivo de este trabajo fue evaluar cariometricamente las alteraciones causadas por diferentes cepas de T. cruzi en la placenta del ratón. Ratones hembras de 60 días, grávidas, fueron inoculadas, intraperitonealmente, con 2 x 10(5) tripomastigotes sanguíneos de las cepas colombiana, Y, Solivia o RC del T. cruzi. Fueron observadas claras diferencias en las alteraciones cariométricas de las células trofoblásticas gigantes y de las células trofoblásticas de la zona esponjosa. Los resultados demostraron que las cepas colombiana y RC causan alteraciones tanto en las células trofoblásticas gigantes como en las células del trofoblasto esponjoso, mientras que las cepas Y y Bolivia provocan alteraciones solamente en las células trofoblásticas gigantes. Es... |
| Tipo: Journal article |
Palavras-chave: Enfermedad de Chagas Experimental; Trypanosoma cruzi; Ratón; Placenta; Cariometría. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300018 |
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| Alexandre,Tatiana Rodrigues; Lima,Marta Lopes; Galuppo,Mariana Kolos; Mesquita,Juliana Tonini; Nascimento,Matilia Ana do; Santos,Augusto Leonardo dos; Sartorelli,Patricia; Pimenta,Daniel Carvalho; Tempone,Andre Gustavo. |
| Abstract Background Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected diseases. Therefore, the discovery of alternative drugs for treating chronic Chagas disease requires immediate action. In this work, we evaluated the mushroom Pleurotus salmoneostramineus in the search for potential antiparasitic compounds. Methods Fruit bodies of the basidiomycete Pleurotus salmoneostramineus were triturated and submitted to organic solvent extraction. After liquid-liquid partition of the crude extract, three fractions were obtained and the bioguided fractionation study was conducted to isolate... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pleurotus salmoneostramineus; Ergosterol; Trypanosoma cruzi; Mechanism of action. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100313 |
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| Ferreira,Daiane Dias; Mesquita,Juliana Tonini; Silva,Thais Alves da Costa; Romanelli,Maiara Maria; Batista,Denise da Gama Jaen; Silva,Cristiane França da; Gama,Aline Nefertiti Silva da; Neves,Bruno Junior; Melo-Filho,Cleber Camilo; Soeiro,Maria de Nazare Correia; Andrade,Carolina Horta; Tempone,Andre Gustavo. |
| Abstract Background: Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods: In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its action mode using cell biology and in silico approaches. Results: Sertraline demonstrated in vitro efficacy against intracellular amastigotes of both T. cruzi strains inside different host cells, including cardiomyocytes, with IC50 values between 1 to 10 μM, and activity against bloodstream trypomastigotes, with IC50 of 14 μM. Considering the mammalian cytotoxicity, the drug resulted in a selectivity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trypanosoma cruzi; Drug; Treatment; Sertraline; Drug repurposing; Drug repositioning. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100321 |
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| Jiménez-Coello,Matilde; Acosta-Viana,Karla; Guzmán-Marín,Eugenia; Bárcenas-Irabién,Alejandra; Ortega-Pacheco,Antonio. |
| AbstractBackground The American trypanosomiasis is a zoonosis caused by the protozoaTrypanosoma cruzi (T. cruzi). The disease is widely distributed throughout the American continent, affecting a wide range of hosts, including dogs. It is present in the canine population in the State of Yucatan, Mexico. However, no significant studies in owned dogs have been performed in the metropolitan area of Merida. A transversal study was conducted in 370 owned dogs from Merida, Yucatan, Mexico.Methods A cross-sectional study including 370 dogs was performed in a major city of Yucatan, Mexico, to detect IgG antibodies against T. cruzi. A commercial ELISA test kit was used and a chi-square test used to evaluate associated risk factors; odds ratio (OR) and 95 %... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trypanosoma cruzi; Epidemiology; Owned dogs; Major city; Mexico. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100343 |
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| Pavão,Beatriz Philot; Demarque,Kelly Cristina; Batista,Marcos Meuser; Oliveira,Gabriel Melo de; Silva,Cristiane França da; Silva,Francisca Hildemagna Guedes da; Caputo,Luzia Fátima Gonçalves; Cascabulho,Cynthia Machado; Barcinski,Marcello André; Soeiro,Maria de Nazaré Correia. |
| Abstract Background: Autologous whole blood (AWB) administration is described as alternative/complementary medical practice widely employed in medical and veterinary therapy against infections, chronic pathologies and neoplasias. Our aim is to investigate in vivo biological effect of AWB using healthy murine models under the course of Trypanosoma cruzi acute infection. Methods: The first set of studies consisted of injecting different volumes of AWB and saline (SAL) into the posterior region of quadriceps muscle of healthy male Swiss mice under distinct therapeutic schemes evaluating: animal behavior, body and organ weight, hemogram, plasmatic biochemical markers for tissue damage and inflammatory cytokine levels and profile. To assess the impact on the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Autologous blood; Alternative therapy; Mouse models; Trypanosoma cruzi. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100316 |
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| Eloy,LJ; Lucheis,SB. |
| Canine trypanosomiasis, caused by protozoans of the genus Trypanosoma, is divided into two primary types: the American form (Chagas disease), due to Trypanosoma cruzi infection, and the African form (sleeping sickness or surra), provoked by Trypanosomaevansi. This disease was originally enzootic and affected only wild animals, including mammals and birds, which served as reservoirs. Later, it spread to domestic animals such as horses, cattle and dogs. The disease became a zoonosis when contact between rural inhabitants and natural Trypanosoma foci occurred, due to ecological imbalances and increasing migration. Dogs are significantly involved in this context, because they are the main domestic animals and participate in the transmission and maintenance... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Canine trypanosomiasis; Trypanosoma cruzi; Trypanosoma evansi; Chagas disease; Surra. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000400002 |
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| Gatto,Mariana; Oliveira,Larissa Ragozo Cardoso; Dias,Fernanda De Nuzzi; Araújo Júnior,João Pessoa; Lima,Carlos Roberto Gonçalves; Lordelo,Eliana Peresi; Santos,Rodrigo Mattos dos; Kurokawa,Cilmery Suemi. |
| Abstract Background The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental infection with Trypanosoma cruzi, strains JLP or Y. Methods The mRNA expression of cytokines and parasite load were assessed by q-PCR. Dependent groups were compared using Student's paired t-test and independent groups were compared using Student's unpaired t-test. Results Infection with the JLP or Y strains increased expression of IFN-γ in the heart and of IL-10 and IL-17 in the spleen and heart compared to uninfected animals. Treatment increased the expression of IFN-γ and decreased the expression of IL-17, IL-10, TGF- β and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chagas disease; Trypanosoma cruzi; Immune response; Cytokines; Q-PCR. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100320 |
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| Oliveira,LRC; Picka,MCM; Nicolete,VC; Calvi,SA; Marcondes-Machado,J. |
| The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trypanosoma cruzi; PCR; Hemoculture; Organs; Distribution. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005 |
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| Lucheis,S. B.; Da Silva,A. V.; Araújo Jr,J. P.; Langoni,H.; Meira,D. A.; Marcondes-Machado,J.. |
| Among domestic animals, dogs are considered to be the major reservoirs of trypanosomatids and, due to their proximity to man, the presence of these parasites in dogs is an alert to actions aiming at triatomine control. Fifty dogs (26 males and 24 females), aged from 2 months to 15 years, belonging to 30 chronic Chagas disease individuals from 15 different municipalities in the western region of São Paulo State, Brazil, were subjected to blood collection for the following tests: artificial xenodiagnosis, blood culture, and Polymerase Chain Reaction (PCR). Forty-three (86%) out of 50 dogs were positive to at least one of the tests performed; 34 (68%) were positive to xenodiagnosis, 30 (60%) to blood culture, and 25 (50%) to PCR for T. cruzi and/or T.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trypanosoma cruzi; T. rangeli; Dog; Xenodiagnosis; Blood culture; Polymerase chain reaction. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400009 |
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| Schaefer,Carl W.. |
| The Neotropical Chagas' disease vectors are classified as members of the reduviid subfamily Triatominae. However, this classification has been suggested to be incorrect, and the suggestion has been treated as fact by some authors; the suggestion is that some (all?) groups in Triatominae had different nontriatomine reduviid ancestors. In this article I raise this question explicitly and ask other questions ancillary to it. I do not answer these questions. Of particular interest is the systematic position of Linshcosteus, the only genus of Triatominae all of whose species occur outside the New World (in India). Related to this question is that of the origin(s) of the several species and populations probably derived from the tropicopolitan Triatoma... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insecta; Chagas' disease; Trypanosoma cruzi; Rhodnius; Linshcosteus; Cladistics. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000100001 |
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| Registros recuperados: 95 | |
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