Data/hora: 13/06/2024 09:52:51

Provedor de dados: | 17
País: | United Kingdom
Título: | A Study on the Origin of Peroxisomes: Possibility of Actinobacteria Symbiosis
Autores: | Duhita Narendra; Saruhashi Satoshi; Hamada Kazuo; Miyata Daisuke; Horiike Tokumasa; Shinozawa Takao.
Data: | 2008-05-07
Ano: | 2008
Palavras-chave: | Genetics &amp; Genomics; Evolutionary Biology.
Resumo: | The origin of peroxisomes as having developed from the endoplasmic reticulum (ER) was proposed on the basis of the similarity between some peroxisomal proteins and ER proteins, and the localization of some peroxisomal proteins on the ER. To study the evolutionary distance between peroxisomes and ER and Prokaryotes, we carried out a phylogenetic analysis of CDC48 (cell division control 48) and its homologs, including ER-localized CDC48, CDC48 homologs in Prokaryotes and peroxisome-localized PEX1 and PEX6. A similarity search analysis of peroxisomal protein sequences to prokaryotic protein sequences using BLAST at several thresholds (E-values) was also done. We propose Actinobacteria symbiosis for the origin of peroxisomes based on the following evidence: (1) PEX1 and PEX6 are close in distance to CDC48 homologs in Actinobacteria, and these distances are closer than to ER-localized CDC48. (2) Actinobacteria proteins show the highest degree of similarity to peroxisomal proteins compared with other prokaryotes.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/1866/version/1

oai:nature.com:10101/npre.2008.1866.1

http://hdl.handle.net/10101/npre.2008.1866.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License