Data/hora: 03/06/2024 02:35:19

Provedor de dados: 	Nature Precedings	
País: 	United Kingdom	
Título: 	Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema.	
Autores: 	Rehab J. Al-Jamal; Linda Wilson; Chris J. Armit; Susan McIntyre; Mark Marsden; Steven D. Shapiro; David J. Harrison.	
Data: 	2007-07-12	
Ano: 	2007	
Palavras-chave: 	Pharmacology.	
Resumo: 	Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema. We show a single dose of a monoclonal antibody against beta1 integrin induced both functional and structural reversal of elastase-induced lung injury in vivo, and we found that similar matrix remodelling changes occurred in human lung tissue. We also identified a potential mechanism of action as this  allosteric modulation of beta1 integrin inhibited elastase-induced caspase activation, F-actin aggregate formation and changes in cellular ATP levels. This was accompanied by maintenance of beta1?integrin levels and inhibition of caveolin-1 phosphorylation. We propose that allosteric modulation of beta1 integrin-mediated mechanosensing prevents cell death associated with lung injury and progressive emphysema, thus allowing cells to survive and for repair and regeneration to ensue.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/437/version/1

oai:nature.com:10101/npre.2007.437.1

http://hdl.handle.net/10101/npre.2007.437.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License