Data/hora: 03/06/2024 01:26:28

Provedor de dados: | Nature Precedings
País: | United Kingdom
Título: | Glucocorticoids Inhibit Sodium Depletion-induced Salt Appetite in Rat
Autores: | Chao Liu; Jing Guan; Ying Chen; Kunshen Liu.
Data: | 2010-12-09
Ano: | 2010
Palavras-chave: | Neuroscience; Pharmacology.
Resumo: | Glucocorticoids, produced in adrenal cortex, exert potent natriuretic and diuretic actions in the kidney. Recently, it has been found that glucocorticoids could upregulate the expression of natriuretic peptide receptor A (NPR-A), the primary receptor of atrial natriuretic peptide, in the hypothalamus of the rat. Consequently, systemic administration of glucocorticoid could block dehydration-induced water intake by activation hypothalamic NPR-A. We describe here glucocorticoids could inhibit sodium intake when administrated systemically in conscious, salt-depleted rats; an effect which was strong and long-lasting. The study provided further evidence for the actions of glucocorticoids on central nervous system, which together with their established renal actions coordinated to normalize extracellular fluid volume.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/5376/version/1

oai:nature.com:10.1038/npre.2010.5376.1

http://dx.doi.org/10.1038/npre.2010.5376.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License