Data/hora: 03/06/2024 02:43:12

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	mGluR5 knockout mice exhibit normal conditioned place-preference to cocaine	
Autores: 	Melissa  A. Fowler; Andrew L. Varnell; Donald C. Cooper.	
Data: 	2011-08-02	
Ano: 	2011	
Palavras-chave: 	Neuroscience; Pharmacology.	
Resumo: 	Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine. Unlike the previous finding, here we show that compared to mGluR5 +/+ mice, -/- mice exhibit no difference in the locomotor response to low to moderate doses of cocaine (10 or 20 mg/kg). A high dose of cocaine (40 mg/kg) resulted in a blunted rather than absent locomotor response. We tested mGluR5 -/- and +/+ mice for conditioned place-preference to cocaine and found no group differences at a conditioning dose of 10 mg/kg, suggesting normal conditioned rewarding properties of cocaine. These results differ substantially from Chiamulera et al. (2001) and replicates Olsen et al., (2010), who found normal cocaine place-preference in mGluR5 -/- mice at 5 mg/kg. Our results indicate mGluR5 receptors exert a modulatory rather than necessary role in cocaine-induced locomotor stimulation and exert no effect on the conditioned rewarding effects of cocaine.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/6180/version/1

oai:nature.com:10101/npre.2011.6180.1

http://hdl.handle.net/10101/npre.2011.6180.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License