Data/hora: 12/06/2024 15:30:59

Provedor de dados: 	Nature Precedings	
País: 	United Kingdom	
Título: 	Inflammation targets specific organs for cancer in carriers of BRCA1/2 pathway mutations	
Autores: 	Bernard Friedenson.	
Data: 	2010-02-18	
Ano: 	2010	
Palavras-chave: 	Cancer; Genetics &amp; Genomics; Immunology; Microbiology.	
Resumo: 	Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast/ovarian cancer that are so high and apparently so selective that many mutation carriers choose to have the most likely targets for cancer surgically removed.  Recent research has focused on better methods of treating such seemingly unavoidable hereditary cancers.  Prevention has received much less attention so a positive test result for a cancer gene leaves carriers with very limited options.  &amp;#xd;&amp;#xa;In order to prevent BRCA1/2 related cancers, it may be important to understand why they seem to occur only in certain characteristic organs.   Results here show that mutations in a pathway depending on BRCA1/2 gene products magnify cancer risks from chronic infection and inflammation, making them especially important in selecting the site where hereditary cancer develops.   Controlling chronic infections and inflammation may be a helpful option to prevent or delay cancers in mutation carriers.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/4225/version/1

oai:nature.com:10101/npre.2010.4225.1

http://hdl.handle.net/10101/npre.2010.4225.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License