Data/hora: 03/06/2024 02:20:36

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	On the origin of the mitochondrial genetic code: Towards a unified mathematical framework for the management of genetic information	
Autores: 	Diego Luis Gonzalez; Simone Giannerini; Rodolfo Rosa.	
Data: 	2012-04-03	
Ano: 	2012	
Palavras-chave: 	Genetics &amp; Genomics; Molecular Cell Biology; Evolutionary Biology.	
Resumo: 	The origin of the genetic code represents one of the most challenging problems in molecular evolution. The genetic code is an important universal feature of extant organisms and indicates a common ancestry of different forms of life on earth. Known variants of the genetic code can be mainly divided in mitochondrial and nuclear classes. Here we provide a new insight on the origin of the mitochondrial genetic code: we found that its degeneracy distribution can be explained by using a mathematical approach recently developed for the description of the Euplotes nuclear variant of the genetic code. The results point to a primeval mitochondrial genetic code composed of four base codons, which we call tesserae, that, among other features, exhibit outstanding error detection capabilities. The theoretical description suggests also a formulation of a plausible biological theory about the origin of protein coding. Such theory is based on the symmetry properties of hypothetical primeval chemical adaptors between nucleic acids and amino acids (ancient tRNA&amp;#x2019;s). Our paper provides a unified mathematical framework for different hypotheses on the origin of genetic coding. Also, it contributes to revisit our present view about the evolutionary steps that led to extant genetic codes by giving a new first-principles perspective on the difficult problem of the origin of the genetic code, and consequently, on the origin of life on earth.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/7136/version/1

oai:nature.com:10.1038/npre.2012.7136.1

http://dx.doi.org/10.1038/npre.2012.7136.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License