Data/hora: 12/06/2024 14:35:54

Provedor de dados: | Nature Precedings
País: | United Kingdom
Título: | A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory
Autores: | John Morley; Susan Farr; William Banks; Steven N. Johnson; Kelvin A. Yamada; Lin Xu.
Data: | 2008-07-24
Ano: | 2008
Palavras-chave: | Neuroscience.
Resumo: | Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer&amp;#x27;s disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear. In these studies, low doses of A[beta] enhanced memory retention in two memory tasks and enhanced acetylcholine production in the hippocampus _in vivo_. We then tested whether endogenous A[beta] has a role in learning and memory in young, cognitively intact mice by blocking endogenous A[beta] in healthy 2-month-old CD-1 mice. Blocking A[beta] with antibody to A[beta] or DFFVG (which blocks A[beta] binding) or decreasing A[beta] expression with an antisense directed at the A[beta] precursor APP all resulted in impaired learning in T-maze foot-shock avoidance. Finally, A[beta]1-42 facilitated induction and maintenance of long term potentiation in hippocampal slices, whereas antibodies to A[beta] inhibited hippocampal LTP. These results indicate that in normal healthy young animals the presence of A[beta] is important for learning and memory.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/2119/version/1

oai:nature.com:10101/npre.2008.2119.1

http://hdl.handle.net/10101/npre.2008.2119.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License