Data/hora: 12/06/2024 14:26:11

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	Antidiabetic, Anti-hyperlipidemic &amp;#x26; Hepatoprotective effect of a Polyherbal Unani formulation &amp;#x201c;Qurs Tabasheer&amp;#x201d; in STZ-diabetic wistar rats	
Autores: 	Danish  Ahmed; Manju Sharma; Alok  Mukerjee; Raja Kamal Kant; Vikas  Kumar.	
Data: 	2012-03-31	
Ano: 	2012	
Palavras-chave: 	Pharmacology; Plant Biology.	
Resumo: 	The present study was undertaken to evaluate the antihyperglycemic, antihyperlipidemic and hepatoprotective effect of a traditional unani formulation &amp;#x201c;Qurs Tabasheer&amp;#x201d; in streptozotocin (STZ) induced diabetic wistar rats. Up until now, no study was undertaken to appraise the efficacy of &amp;#x201c;Qurs Tabasheer&amp;#x201d; in the diabetic rats. Qurs Tabasheer is a unani formulation restraining preparations from six various herbs namely Tukhme Khurfa (Portulaca oleracea seed), Gule Surkh (Rosa damascena flower), Gile armani (Arminium bole), Gulnar (Punica granatum flower), Tabasheer (Bambusa arundinasia dried exudate on node), Tukhme Kahu (Lactuca sativa Linn seed). The effect of Qurs Tabasheer was assessed in STZ (60 mg/kg, i.p single shot) induced diabetic wistar rats. STZ produced a marked increase in the serum glucose, total cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides and trimmed down the HDL level. We have weighed the effect of Qurs Tabasheer on hepatic activity through estimating levels of various liver enzymes viz. Hexokinase, Glucose-6-Phosphatase and Fructose-1-6-biphosphatase in STZ diabetic wistar rats. In STZ-induced diabetic wistar rats the level of Hexokinase, and Glucose-6-Phosphatase was decreased to a significant level while the level of fructose-1-6-biphophatase was augmented. Therapy with Qurs Tabasheer for 30 days to STZ-induced diabetic rats significantly reduces the level of serum glucose, total cholesterol, triglycerides, glucose-6-phosphatase and fructose-1-6-biphosphatase, while magnitude of HDL cholesterol and hexokinase was amplified. Antihyperglycemic, antihyperlipidemic activity of Qurs Tabasheer suspension in STZ- induced wistar rats was found to be more effective than oral hypoglycemic drug Glimepiride.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/7056/version/1

oai:nature.com:10101/npre.2012.7056.1

http://hdl.handle.net/10101/npre.2012.7056.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License