Data/hora: 03/06/2024 03:43:12

Provedor de dados: 	Nature Precedings	
País: 	United Kingdom	
Título: 	A Novel Thermodynamic Method For Quantifying Ligand-Receptor Interactions: The IC (1/3) Standard Vs IC (50)	
Autores: 	Dr Sudarsan Prasad.	
Data: 	2011-06-06	
Ano: 	2011	
Palavras-chave: 	Pharmacology.	
Resumo: 	A method based on the Concentration Derivative Product (CDP) is proposed to analyze the thermodynamics of Drug-Receptor interactions. CDP is defined as the product of the fractional inhibition f and it&amp;#x2019;s concentration derivative. Assuming Michaelis-Menten kinetics, it is shown that for a number of drug-receptor systems (HIV protease, ACE, HMG-CoA, Opioid receptor inhibitors, etc.) f max  = 0.333, irrespective of the nature of bonding interactions and Ki.   The CDP max = [4 / ( 27 Ki ) ], and gives a measure of the drug potency directly. CDP also gives thermodynamic information about the ratio of the gradients of the inhibitor chemical potential in the free and bound states.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/6006/version/1

oai:nature.com:10.1038/npre.2011.6006.1

http://dx.doi.org/10.1038/npre.2011.6006.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License