Data/hora: 03/06/2024 04:21:31

Provedor de dados: | Nature Precedings
País: | United Kingdom
Título: | Ajuvant effect of a Synthetic Aluminium - Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei.
Autores: | madike ezeibe; obianuju obianuju Okoroafor; nnenna elendu-eleke; Augustine Ngene.
Data: | 2012-01-02
Ano: | 2012
Palavras-chave: | Pharmacology.
Resumo: | Abstract effect of a synthetic Aluminium - Magnesium Silicate (AMS) on antiplasmodial activity of chloroquine was tested. Plasmodium berghei-infected mice were treated with 7 mg/kg, 5 mg/kg and 3 mg/kg chloroquine, respectively. The two subgroups in each experiment were treated with chloroquine alone and with chloroquine in AMS respectively. Parasitaemia (%) of the group treated with 7 mg/kg was higher than that of the control. At 5 mg/kg, chloroquine treatment significantly reduced parasitaemia from 3.60 to 2.46 (P =0.01). Incorporating chloroquine in AMS significantly improved its ability to reduce P. berghei parasitaemia at 5 mgkg and at 3 mg/kg, from 2.46 0.21 to 1.57 0.25 (P = 0.01) and from 3.82 0.06 to 2.12 0.08 (P =0.01 ). It also increased mortality of mice treated at 7 mg/kg from 20 to 80 %.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/6749/version/1

oai:nature.com:10101/npre.2012.6749.1

http://hdl.handle.net/10101/npre.2012.6749.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License