Data/hora: 03/06/2024 02:45:17

Provedor de dados: | 17
País: | United Kingdom
Título: | A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast
Autores: | Aviv de Morgan; Leonid  Brodsky; Yefim Ronin; Eviatar Nevo; Abraham Korol; Yechezkel Kashi.
Data: | 2008-01-27
Ano: | 2008
Palavras-chave: | Genetics &amp; Genomics; Evolutionary Biology.
Resumo: | The association between transcription and DNA repair is acknowledged as a player in the generation of mutations in a non-random fashion in prokaryotes and eukaryotes. Previous studies demonstrated that the transcription complex is capable of directing DNA repair to sites of transcription. This process is especially important to growth-arrested cells, in which many DNA repair capacities are diminished; it may also lead to mutations preferentially in transcribed genes. Using microarray analysis of growth-arrested yeast cultures, we demonstrated on a genomic scale, the co-localization of a DNA-turnover marker, indicative of DNA-repair-associated DNA synthesis, with genes persistently transcribed during stationary phase. This may serve as a clue regarding the non-random manner in which non-dividing cells may potentially mutate in the absence of replication, solely as a result of their inherent, transcriptional stress response.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/1543/version/1

oai:nature.com:10101/npre.2008.1543.1

http://hdl.handle.net/10101/npre.2008.1543.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License