Data/hora: 13/06/2024 21:46:33

Provedor de dados: | 17
País: | United Kingdom
Título: | Aluminium - Magnesium Silicate enhances antibacterial activity of Ampicillin trihydrate, against Salmonella gallinarum
Autores: | Madike Ezeibe; George Anosa; Okechi Okorie; Nnenna Elendu-Eleke; Obianuju Okoroafor; Augustine Ngene; Ogechukwu Chikelu.
Data: | 2012-01-20
Ano: | 2012
Palavras-chave: | Pharmacology.
Resumo: | Solutions of different concentrations, of Ampicillin trihydrate (AT) and of a formulation of AT in Aluminium Magnesium Silicate (AMS), were used for sensitivity test on Salmonella gallinarum cultures. Also, S. gallinarum-infected chicks were treated with; 10 mg / Kg (AT), 10 mg / Kg (AT in AMS), 7.5 mg / Kg ( AT), 7.5 mg /Kg (AT in AMS). Mean inhibition area, 28.39 mm produced by AT did not vary significantly (P ) from 26.36 mm produced by AT in AMS. However, 17.5 105 Salmonella gallinarum culture forming units per ml of bile of the untreated chicks and 3.4 105 (80.58 % reduction), 2.5 105 (85.7 % reduction) , 5.4 105 (69.2 % reduction ) and 0.38 105 (97.8 % reduction ) of the respective treated groups, showed AMS significantly (P 0.01) improved AT`s ability to clear the infection, in vivo.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/6814/version/1

oai:nature.com:10101/npre.2012.6814.1

http://hdl.handle.net/10101/npre.2012.6814.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License