Data/hora: 13/06/2024 04:44:00

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	A network-based signaling mechanism of cancer development and progression	
Autores: 	Edwin Wang.	
Data: 	2008-08-27	
Ano: 	2008	
Palavras-chave: 	Cancer; Genetics &amp; Genomics; Bioinformatics.	
Resumo: 	We conducted a comprehensive analysis of a manually curated human signaling network containing 1634 nodes and 5089 signaling regulatory relations by integrating cancer-associated genetically and epigenetically altered genes. We find that cancer mutating genes are enriched in positive signaling regulatory loops, whereas the cancer-associated methylating genes are enriched in negative signaling regulatory loops. We further characterized an overall picture of the cancer-signaling architectural and functional organization. From the network, we extracted an oncogene-signaling map, which contains 326 nodes, 892 links and the interconnections of mutated and methylated genes. The map can be decomposed into 12 topological regions or oncogene-signaling blocks, including a few &amp;#x2018;oncogenic-signaling-addictive blocks&amp;#x27; in which frequently used oncogenic signaling events are enriched.&amp;#xd;&amp;#xa;&amp;#xd;&amp;#xa;Large scale sequencing of cancer genomes has shown that there is a lot of diversity and little overlap in terms of the different types of mutated genes. This diversity is seen among different types of tumours and even between tumours that originate from the same tissue. Despite the complexity of these mutations, the cancer signalling map allows them to be divided into a few common signaling modules and therefore uncovers the underlying logic of cancer signaling. Both common and tumor-type specific signaling modules are observed. The common module contains genes that are frequently mutated in most tumors regardless of tumor-type. However, the common module is generally not sufficient for tumorigenesis, because mutations of the genes in the common module are frequently accompanied by mutations in one or two other signaling modules. Different tumor types appear to achieve tumorigenesis via distinct mechanisms, i.e., through collaboration between different signaling modules. Taking a systems-biology approach, the researchers present a network view of molecular mechanisms of cancer signaling that will shape our understanding of fundamental tumor cell biology.&amp;#xd;&amp;#xa;	
Tipo: 	Presentation	
Identificador: 	http://precedings.nature.com/documents/2238/version/1

oai:nature.com:10.1038/npre.2008.2238.1

http://dx.doi.org/10.1038/npre.2008.2238.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License