Data/hora: 04/06/2024 01:34:47

Provedor de dados: | Nature Precedings
País: | United Kingdom
Título: | Evolution of 11[beta]-Hydroxysteroid Dehydrogenase-Type 1 and 11[beta]-Hydroxysteroid Dehydrogenase-type 3
Autores: | Michael E. Baker.
Data: | 2010-03-19
Ano: | 2010
Palavras-chave: | Developmental Biology; Ecology; Genetics &amp; Genomics; Earth &amp; Environment; Evolutionary Biology.
Resumo: | A key regulator of glucocorticoid action is 11[beta]-hydroxysteroid dehydrogenase type-1 (11[beta]-HSD1), which catalyzes the conversion of cortisone to cortisol, the biologically active glucocorticoid.  11[beta]-HSD1 is a paralog of 11[beta]-HSD3, whose physiological function remains unclear.  As reported here, 11[beta]-HSD3 has orthologs in sea urchin, amphioxus and Ciona, while 11[beta]-HSD1 first appears in sharks.  Thus, 11[beta]HSD3 arose before the evolution of glucocorticoid signaling, suggesting different ancestral function(s) for 11[beta]-HSD3.  Four perplexing findings arise from this evolutionary analysis: 1) 11[beta]-HSD1 is not present in a ray-finned fish genome, 2) zebrafish and fathead minnow contain two isoforms of 11[beta]-HSD3; 3) neither rat nor mouse contain 11[beta]-HSD3 and 4) amphioxus contains sixteen 11[beta]-HSD3 paralogs.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/4296/version/1

oai:nature.com:10101/npre.2010.4296.1

http://hdl.handle.net/10101/npre.2010.4296.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License