Data/hora: 29/05/2024 06:17:25

Provedor de dados: | Nature Precedings
País: | United Kingdom
Título: | Using Ontology Fingerprints to Evaluate Genome-wide Association Results
Autores: | Lam Tsoi; Michael Boehnke; Richard Klein; Jim Zheng.
Data: | 2009-07-29
Ano: | 2009
Palavras-chave: | Genetics &amp; Genomics; Bioinformatics.
Resumo: | We describe an approach to characterize genes or phenotypes via ontology fingerprints which are composed of Gene Ontology (GO) terms overrepresented among those PubMed abstracts linked to the genes or phenotypes. We then quantify the biological relevance between genes and phenotypes by comparing their ontology fingerprints to calculate a similarity score. We validated this approach by correctly identifying genes belong to their biological pathways with high accuracy, and applied this approach to evaluate GWA study by ranking genes associated with the lipid concentrations in plasma as well as to prioritize genes within linkage disequilibrium (LD) block.  We found that the genes with highest scores were: ABCA1, LPL, and CETP for HDL; LDLR, APOE and APOB for LDL; and LPL, APOA1 and APOB for triglyceride. In addition, we identified some top ranked genes linking to lipid metabolism from the literature even in cases where such knowledge was not reflected in current annotation of these genes.  These results demonstrate that ontology fingerprints can be used effectively to prioritize genes from GWA studies for experimental validation.
Tipo: | Presentation

Identificador:

http://precedings.nature.com/documents/3513/version/1

oai:nature.com:10.1038/npre.2009.3513.1

http://dx.doi.org/10.1038/npre.2009.3513.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License