Data/hora: 08/06/2024 14:07:05

Provedor de dados: | 19
País: | Japan
Título: | Active Immunization Against 5α-androstane-3α, 17β-diol Increases Ovulation Rate in Merino Ewes
Autores: | TETSUKA, Masafumi; NANCARROW, Colin. D.; 手塚, 雅文.
Data: | 2001
Ano: | 2001
Palavras-chave: | Ovulation rate; Sheep; Immunization; 5a-reduced androgen.
Resumo: | Cyclic Merino ewes were immunized three times against 5α−androstane-3α,17β-diol (3α-diol) at three week intervals (weeks 0,3 and 6). After the third immunization, estrous cycles were synchronized by a series of PG injections and intensive blood samples were obtained for gonadotropin analyses during the mid-luteal phase and during the early follicular phase. Ovulation rates were determined after each immunization and subsequent cloprostenol (PG)-induced luteolysis (weeks 3, 6, 8 and 11). After the second immunization, daily blood samples were obtained and concentrations of plasma progesterone (P) were measured. Immunization against 3α-diol significantly increased the ovulation rate after the second and third immunizations and at week 10 (P&lt;0.01, P&lt;0.01 and P&lt;0.05 respectively). It also induced anovulation in several ewes. Plasma concentrations of P were significantly increased by 3α-diol immunization (P&lt;0.01). Pulse frequency of LH and concentrations of FSH were also increased during the luteal phase (P&lt;0.01 and P&lt;0.05 respectively). There was a significant correlation between the mean concentrations of FSH during the luteal phase and the subsequent ovulation rates (P&lt;0.01). These results indicate that immunization against 3α-diol increases ovulation rate in ewes and its effect was, at least partially, exerted by increased plasma concentrations of FSH.
Idioma: | Inglês
Identificador: | http://ir.obihiro.ac.jp/dspace/handle/10322/3033
Editor: | 日本繁殖生物学会
Formato: | application/pdf
Fonte: | 日本繁殖生物学会