Data/hora: 08/06/2024 12:54:47

Provedor de dados: 	19	
País: 	Japan	
Título: 	Fucoidan prevents concanavalin A-induced liver injury through induction of endogenous IL-10 in mice	
Autores: 	Saito, Ako; Yoneda, Masashi; Yokohama, Shiro; Okada, Mitsuyoshi; Haneda, Masakazu; Nakamura, Kimihide; 中村, 公英.	
Data: 	2006-07	
Ano: 	2006	
Palavras-chave: 	Concanavalin A; Fucoidan; Liver injury; Cytokine; Kupffer cell; Scavenger receptor.	
Resumo: 	Fucoidan is a complex of sulfated polysaccharides derived from non-mammalian origin such as marine brown algae and induces cytokine expression. We investigated the effect of fucoidan on concanavalin A (Con A)-induced liver injury in mice. Liver injury was induced by an intravenous injection of Con A (18.5 mg/kg). Various doses of fucoidan (1-30 mg/kg) were intravenously administered 30 min before Con A injection. The plasma alanine aminotransferase (ALT) and several cytokines levels were determined, and hepatic histological changes were also assessed. The effect of fucoidan administration by itself on induction of interleukin (IL)-10 in plasma and liver tissue was investigated. Con A administration induced an elevation of plasma ALT level, and fucoidan administration dose-dependently prevented the Con A-induced elevation of plasma ALT. Con A administration increased plasma TNF-alpha and IFN-gamma levels, and fucoidan pretreatment significantly inhibited these alterations and increased plasma IL-10 level. The inhibitory effect of fucoidan on Con A-induced liver injury and production of proinflammatory cytokines were reversed by anti-mouse IL-10 antibody pretreatment. Fucoidan induced the IL-10 production in plasma and liver tissue. These findings suggest that fucoidan prevents Con A-induced liver injury by mediating the endogenous IL-10 production and the inhibition of proinflammatory cytokine in mice. (c) 2006 Elsevier Ireland Ltd. All rights reserved.	
Idioma: 	Inglês	
Identificador: 	http://ir.obihiro.ac.jp/dspace/handle/10322/66	
Editor: 	ELSEVIER	
Formato: 	application/pdf