Data/hora: 06/06/2024 00:25:24

Provedor de dados: 	19	
País: 	Japan	
Título: 	トキソプラズマ溶解抗原(TLA)で誘導されるマウス脾臓内の細胞障害性細胞の性質

Characteristics of Cytotoxic Cells Induced by Toxoplasma Lysate Antigen in Mouse Spleen	
Autores: 	MIYAHARA, Kazuro; MATSUMOTO, Toru; TOSE, Shinichi; SAKURAI, Haruhisa; IGARASHI, Ikuo; SAITO, Atsushi; HIROSE, Tsuneo; SUZUKI, Naoyoshi; 宮原, 和郎; 五十嵐, 郁男.	
Data: 	1992	
Ano: 	1992	
Palavras-chave: 	Cytotoxic activity; Mouse; Phenotype; Spleen cell; Toxoplasma lysate antigen.	
Resumo: 	Spleen cells from Toxoplasma lysate antigen (TLA)-sensitized BALB/c mice showed the strong cytotoxic activity against both natural killer (NK)-sensitive cells (YAC-1 and RL♂-1) and NK-insensitive cells (P-815), when incubated with TLA or recombinant human IL-2 (rhIL-2). The increment of TLA concentration in culture medium increased the cytotoxic activity. Treatment of effector cells; spleen cells from TLA-sensitized mice incubated with TLA, with anti-asialo GM1 or anti-Thy-1 plus complement inhibited the cytotoxic activity of effector cells, whereas treatment with anti-mouse Lyt-2.2 serum plus complement had no effect on the cytotoxic activity. Treatment of spleen cells from TLA-sensitized mice with anti-asialo GM1 and/or anti-Thy-1 plus complement inhibited cytotoxic activities of effector cells. These results suggested that spleen bells sensitized with TLA both in vivo and in vitro were asialo GM1 positive and Thy-1 positive; and the majority of cytotoxic cells induced by TLA were similar to lymphokine-activated killer (LAK)cells induced by IL-2.	
Idioma: 	Inglês	
Identificador: 	http://ir.obihiro.ac.jp/dspace/handle/10322/4063	
Editor: 	日本獣医学会	
Fonte: 	日本獣医学会