Data/hora: 01/06/2024 02:42:14

Provedor de dados: | Obihiro University of Agriculture and Veterinary Medicine Academic Repository (OAK)
País: | Japan

Título:

1，2-ジメチルヒドラジン投与マウスにおける大腸腺腫発症に与える食餌性ナガイモの効果

Prevention of Aberrant Crypt Foci Formation by Dietary Chinese Yam (D. opposita THUNB.) in 1，2-Dimethylhydrazine-treated Mice

Autores: | 木下, 幹朗; 柚木, 恵太; 得字, 圭彦; 川原, 美香; 大庭, 潔; 弘中, 和憲; 大西, 正男; Kinoshita, Mikio; Yunoki, Keita; Tokuji, Yoshihiko; Kawahara, Mika; Ohba, Kiyoshi; Hironaka, Kazunori; Ohnishi, Masao.
Data: | 2008
Ano: | 2008
Palavras-chave: | ナガイモ 大腸腺腫 大腸ガン 1，2-ジメチルヒドラジン DNAマイクロアレイ Chinese yam (Nagaimo) aberrant crypt foci colon cancer 1; 2-dimethylhydrazine DNA microarray.
Resumo: | ナガイモのガンに対する機能性を探索する目的で， 1,2- ジメチルヒドラジン投与マウスにおける大腸腺腫(ACF) 発症に与える食餌性ナガイモ粉末の効果を検証した.ナガ イモ粉末をAIN-93G標準飼料のコーンスターチ部分に 100%または50%置き換えて投与したところ，大腸腺腫の 発症が有意に抑制されたまた，加熱および非加熱の生ナ ガイモ粉末ともに同様の効果が認められた. DNAマイク ロアレイを用いて大腸での遺伝子の異同を調べたところ， ナガイモ投与群ではアポ卜ーシスを誘導する遺伝子群の増加が認められた.To clarify the physiological effects of dietary Chinese yam (Nagaimo) on colon cancer in vivo， the effects of dietary Nagaimo on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in the large intestine of mice were investigated. After 8 weeks of feeding raw or boiled Nagaimo and DMH administration，DMH-induced ACF formation was found to be significantly suppressed in the large intestines of all mice. DNA microarray analysis showed that levels of apoptosis-inducing gene expression in the large intestine of animals fed dietary Nagaimo were increased in comparison to those fed the control diet. The results of the present study clear1y demonstrated that DMH-induced ACF formation was inhibited in the mouse large intestine by dietary Nagaimo intake. Daily ingestion of Nagaimo may thus serve to suppress colon carcinoma in humans.
Idioma: | Japonês
Identificador: | http://ir.obihiro.ac.jp/dspace/handle/10322/2706
Editor: | 日本食品科学工学会
Formato: | application/pdf
Fonte: | 日本食品科学工学会