Data/hora: 09/06/2024 02:11:00

Provedor de dados: | 20
País: | Belgium
Título: | An antimalarial cembranolide from Tanzania soft corals, Lobophytum crassum (von Marenzeller (1886) and L. rotundum (Tixier-Durivault (1957)
Autores: | Said, S.A.
Data: | 2006-02-08
Ano: | 2005
Palavras-chave: | Lobophytum crassum; L. rotundum; Plasmodium falciparum; Antimalarial; Soft corals; Cytotoxic; Cembranolide Parasites Coral reefs Brine shrimp eggs Parasites http://aims.fao.org/aos/agrovoc/c_5574.
Resumo: | Bioscreening guided fractionation of the extracts of soft corals Lobophytum crassum and L. rotundum using brine shrimp larvae cytotoxicity assay led to the isolation of a cembranolide diterpene (E,E,E)-6,10,14-trimethyl-3-methylene- 3a,4,7,8,11,12,15,15aoctahydrocylotetradeca [b]furan-2(3H)-one (1). This diterpene, identified as cembranolide compound 1, was found to be active against the multidrug-resistant and chloroquine-sensitive strains of Plasmodium falciparum malaria parasite in vitro. It also possessed cytotoxic properties.
Tipo: | Journal Contribution
Idioma: | Inglês

Identificador:

Western Indian Ocean Journal of Marine Science, 4 (1), p. 95–98

0856-860X

http://hdl.handle.net/1834/1139

Editor: | WIOMSA
Relação: | http://www.wiomsa.org

Formato:

58999 bytes

application/pdf