Data/hora: 06/06/2024 13:49:50

Provedor de dados: 	27	
País: 	Belgium	
Título: 	Live-food mediated drug delivery as a tool for disease treatment in larviculture: the enrichment of therapeutics in rotifers and &lt;i&gt;Artemia&lt;/i&gt; nauplii	
Autores: 	Verpraet, R.; Chair, M.; Léger, P.; Nelis, H.; Sorgeloos, P.; De Leenheer, A.P.	
Data: 	1992	
Ano: 	1992	
Palavras-chave: 	Aquaculture systems; Disease control; Drugs; Food chains; Therapy; Artemia.	
Resumo: 	The live food enrichment technique using emulsions for nutritional deficiencies in rotifers and &lt;i&gt;Artemia&lt;/i&gt; was further investigated as a tool for transferring therapeutics through the food chain. &lt;i&gt;Artemia&lt;/i&gt; nauplii and the rotifer &lt;i&gt;Brachionus plicatilis&lt;/i&gt; were enriched with a self-emulsifying concentrate in which the therapeutic mixture trimetoprim: sulfamethoxazole was incorporated. An analytical method and protocol for the quantification of trimethoprim and sulfamethoxazole in a heterogeneous biological matrix, such as &lt;i&gt;Artemia&lt;/i&gt; , was developed using High Performance Liquid Chromatography. When applying a 24h enrichment period, the accumulation of both drugs in &lt;i&gt;Artemia&lt;/i&gt; nauplii appeared to be linearly related to the concentration of the drugs in the enrichment product. Values of approximately 790 mg/kg of total drugs (protein basis; or 290 mg/kg on dry weight basis) could be obtained. In rotifers, the level of total therapeutics reached a value of about 116,mg/kg (protein basis) after 6h of enrichment. The ratio of the two drugs detected in rotifers was different from the one found in &lt;i&gt;Artemia&lt;/i&gt; , suggesting different accumulation kinetics.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.vliz.be/nl/open-marien-archief?module=ref&refid=2894	
Fonte: 	%3Ci%3EAquacult.+Eng.+11%3C%2Fi%3E%3A+133-139	
Fonte: 	info:eu-repo/semantics/restrictedAccess