Data/hora: 05/06/2024 17:07:52

Provedor de dados: 	27	
País: 	Belgium	
Título: 	Accumulation of trimethoprim, sulfamethoxazole, and &lt;i&gt;N&lt;/i&gt;-acetylsulfamethoxazole in fish and shrimp fed medicated &lt;i&gt;Artemia franciscana&lt;/i&gt;	
Autores: 	Chair, M.; Nelis, H.J.; Leger, P.; Sorgeloos, P.; De Leenheer, A.P.	
Data: 	1996	
Ano: 	1996	
Resumo: 	In a previous paper (H.J. Nelis, P. Léger, P. Sorgeloos, and A.P. De Leenheer, Antimicrob. Agents Chemother. 35:2486-2489, 1991) it was reported that two selected antibacterial agents, i.e. trimethoprim and sulfamethoxazole, can be efficiently bioencapsulated in nauplii of the brine shrimp &lt;i&gt;&lt;i&gt;Artemia&lt;/i&gt; franciscana&lt;/i&gt; for administration to fish. This follow-up study showed that larvae of the sea bass and the turbot as well as postlarvae of the white shrimp accumulate the therapeutic agents in high quantities when fed medicated &lt;i&gt;A. franciscana&lt;/i&gt;. To monitor their levels as a function of time, the liquid chromatographic method originally developed for the analysis of &lt;i&gt;A. franciscana&lt;/i&gt; was modified with respect to chromatography, internal standardization, and sample pretreatment. The levels of trimethoprim ranged from 1 to 7 µg/g (sea bass), 1 to 13µg/g (turbot), and 4 to 38 µg/g (white shrimp). The corresponding values for sulfamethoxazole were 0.3 to 4 µg/g (sea bass), 1 to 42 µg/g (turbot), and 4 to 35µg/g (white shrimp). Only the two fish species, unlike the shrimp, metabolized the latter to &lt;i&gt;N&lt;/i&gt;-acetylsulfamethoxazole (concentration range, 1 to 10 µg/g). These data suggest the potential of the bioencapsulation of therapeutic agents in live food as a tool to control infectious diseases in aquaculture. A preliminary challenge test also confirmed the in vivo efficacy of this approach.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.vliz.be/nl/open-marien-archief?module=ref&refid=2923	
Fonte: 	%3Ci%3EAntimicrob.+Agents+Chemother.+40%287%29%3C%2Fi%3E%3A+1649-1652	
Fonte: 	info:eu-repo/semantics/restrictedAccess