Data/hora: 11/06/2024 17:50:10

Provedor de dados: | 3
País: | Brazil
Título: | Structural features and assessment of zymosan-induced arthritis in rat temporomandibular joint model using sulfated polysaccharide
Autores: | Rodrigues, José Ariévilo Gurgel; Universidade Federal do Ceará; Chaves, Hellíada Vasconcelos; Universidade Federal do Ceará; Alves, Kátia de Souza; Universidade Federal do Ceará; Filgueira, Adriano Aguiar; Universidade Federal do Ceará; Bezerra, Mirna Marques; Universidade Federal do Ceará; Benevides, Norma Maria Barros; Universidade Federal do Ceará.
Data: | 2014-05-08
Ano: | 2014
Palavras-chave: | Chlorophyta; Sulfated polymers; Bioactivity; Inflammatory arthropathies.
Resumo: | The green seaweed Caulerpa cupressoides var. lycopodium contains three SPs fractions (Cc-SP1, Cc-SP2 and Cc-SP3). Cc-SP1andCc-SP2 had anticoagulant (in vitro), pro- and antithrombotic, antinociceptive and/or anti-inflammatory (in vivo) effects. This study analyzed structural features and the antinociceptive and anti-inflammatory effects of Cc-SP1 on zymosan-induced acute arthritis of the rat temporomandibular joint (TMJ). Cc-SP1 was investigated by infrared technique. Male Wistar rats (200-240 g) received subcutaneously (s.c.) Cc-SP1 1h prior to intra-articular (i.art.) injection of zymosan (2 mg joint-1) or saline (0.9%) into the left TMJ. Mechanical hypernociception was measured by the electronic Von Frey method in the basal and 4h after zymosan injection. Animals were euthanized 6h after zymosan injection and the TMJ cavity was removed for total leukocyte counts from the synovial fluid and myeloperoxidase (MPO) activity assessment. Cc-SP1 (1, 3 or 9 mg kg-1) containing sulfate ester, galactose-6-sulfate, uronic acid and glycosidic linkages reduced zymosan-induced hypernociception (78.12, 81.13 and 87.43%, respectively, p &amp;lt; 0.01), and inhibited the total leukocyte influx (85, 88.14 and 89.95%, respectively, p &amp;lt; 0.01), being confirmed by MPO activity (p &amp;lt; 0.05). Therefore, Cc-SP1 reveals a pharmacological tool for treating inflammatory arthropathies.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês

Identificador:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19342

10.4025/actascibiolsci.v36i2.19342

Editor: | Universidade Estadual De Maringá
Relação: | http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19342/pdf_2
Formato: | application/pdf

Fonte:

Acta Scientiarum. Biological Sciences; v. 36, n. 2 (2014); 127-135

Acta Scientiarum. Biological Sciences; v. 36, n. 2 (2014); 127-135

1807-863X

1679-9283

Fonte:

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DECLARAÇÃO DE ORIGINALIDADE E CESSÃO DE DIREITOS AUTORAIS Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade. Declaro, ainda, que uma vez publicado na revista Acta Scientiarum. Biological Sciences, editada pela Universidade Estadual de Maringá, o mesmo jamais será submetido por mim ou por qualquer um dos demais co-autores a qualquer outro meio de divulgação científica. Através deste instrumento, em meu nome e em nome dos demais co-autores, porventura existentes, cedo os direitos autorais do referido artigo à Universidade Estadual de Maringá e declaro estar ciente de que a não observância deste compromisso submeterá o infrator a sanções e penas previstas na Lei de Proteção de Direitos Autorias (Nº9609, de 19/02/98).