Data/hora: 12/06/2024 17:45:31

Provedor de dados: | 42
País: | Brazil
Título: | Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination
Autores: | PEREIRA,FRANCISCO C.; STRADIOTTO,NELSON R.; ZANONI,MARIA VALNICE B.
Data: | 2002-09-01
Ano: | 2002
Palavras-chave: | Miconazole; Voltammetry; Electroanalysis; Determination.
Resumo: | Miconazole is reduced at mercury electrode above pH 6 involving organometallic compound formation, responsible for an anomalous polarographic behavior. The electrodic process presents a large contribution of the adsorption effects. The drug can be determined by cathodic stripping voltammetry from 8.0 x 10-8 to 1, 5 x 10-6 molL-1 in Britton-Robinson buffer pH 8.0, when pre-accumulated for 30s at an accumulation potential of 0V. A relative standard deviation of 3.8% was obtained for ten measurements of 1.0 x 10-7 molL-1 miconazole in B-R buffer pH 8.0 and a limit detection of 1, 7 x 10-8 molL-1 was determined using 60s of deposition time and scan rate of 100 mVs-1. The proposed method is simple, precise and it was applied successfully for the determination of the miconazole in pure form and in commercial formulations, showing mean recoveries of 99.7-98.4%.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000300005
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652002000300005
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.74 n.3 2002
Fonte: | info:eu-repo/semantics/openAccess