Data/hora: 04/06/2024 13:32:57

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Genotoxic and Genoprotective Potential of Black Mulberry (Morus nigra) Fruit	
Autores: 	YILMAZ,SERKAN; UÇAR,ASLI; GÖKTAŞ,BAYRAM.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	Black mulberry; Chromosomal aberrations; Micronucleus; Genotoxicity; Anti-genotoxicity.	
Resumo: 	Abstract: Black Mulberry (Morus nigra L.) belongs to Moraceae family. The present study evaluated the possible genotoxic and/or protective activities of black mulberry fruit juice (BMFJ), in vitro, using mitomycin C (MMC) as a positive control, by chromosomal aberrations and micronucleus assays. Human lymphocytes were treated with BMFJ concentrations alone (1/1, 1/2, 1/4, 1/8 dilutions), pretreatment (49h) (0.20 μg/ml MMC+ 1/1 BMFJ, 0.20 μg/ml MMC+1/2 diluted BMFJ, 0.20 μg/ml MMC+1/4 diluted BMFJ, 0.20 μg/ml MMC+1/8 diluted BMFJ) and simultaneous-treatment (48h) (0.20 μg/ml MMC+ 1/1 BMFJ, 0.20 μg/ml MMC+1/2 diluted BMFJ, 0.20 μg/ml MMC+1/4 diluted BMFJ, 0.20 μg/ml MMC+1/8 diluted BMFJ). The in vitro results demonstrated that BMFJ showed no genotoxicity, but it significantly decreased chromosomal aberration and micronucleus frequency induced by MMC. Our results showed that all concentrations of BMFJ revealed no genotoxicity but protective activity against genomic changes induced by anti-tumor agent MMC in human lymphocytes. Protective effects of BMFJ on MMC induced chromosomal damages most probably due to its free radical scavenging activity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700602	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201920190337	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.91 n.4 2019	
Fonte: 	info:eu-repo/semantics/openAccess